B0FWC7 · COX1_AEDAE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme A groups non-covalently per subunit.
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

Note: Binds a copper B center.

Pathway

Energy metabolism; oxidative phosphorylation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site39Ca2+ (UniProtKB | ChEBI)
Binding site44Ca2+ (UniProtKB | ChEBI)
Binding site60Fe (UniProtKB | ChEBI) of Fe(II)-heme a (UniProtKB | ChEBI); low-spin; axial binding residue
Binding site239Cu cation B (UniProtKB | ChEBI)
Binding site243O2 (UniProtKB | ChEBI)
Binding site289Cu cation B (UniProtKB | ChEBI)
Binding site290Cu cation B (UniProtKB | ChEBI)
Binding site367Mg2+ (UniProtKB | ChEBI); ligand shared with subunit 2
Binding site368Mg2+ (UniProtKB | ChEBI); ligand shared with subunit 2
Binding site375Fe (UniProtKB | ChEBI) of heme a3 (UniProtKB | ChEBI); high-spin; axial binding residue
Binding site377Fe (UniProtKB | ChEBI) of Fe(II)-heme a (UniProtKB | ChEBI); low-spin; axial binding residue

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number
  • Alternative names
    • Cytochrome c oxidase polypeptide I

Gene names

    • Name
      mt:CoI
    • Synonyms
      COI
      , COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • LVPib12
    • Formosus
    • Liverpool
    • Moyo-R
    • Red eye
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Culicinae > Aedini > Aedes > Stegomyia

Accessions

  • Primary accession
    B0FWC7
  • Secondary accessions
    • Q94PR3

Proteomes

    • Identifier
    • Component
      Mitochondrion MT, Unassembled WGS sequence

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane16-36Helical
Transmembrane55-75Helical
Transmembrane101-117Helical
Transmembrane144-164Helical
Transmembrane182-202Helical
Transmembrane233-253Helical
Transmembrane267-287Helical
Transmembrane304-324Helical
Transmembrane337-357Helical
Transmembrane379-399Helical
Transmembrane415-435Helical
Transmembrane451-471Helical

Keywords

PTM/Processing

Features

Showing features for chain, cross-link.

TypeIDPosition(s)Description
ChainPRO_00003472621-514Cytochrome c oxidase subunit 1
Cross-link239↔2431'-histidyl-3'-tyrosine (His-Tyr)

Proteomic databases

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    514
  • Mass (Da)
    56,966
  • Last updated
    2008-09-02 v2
  • Checksum
    019CDFE533655F10
MSRQWLFSTNHKDIGTLYFIFGVWSGMVGTSLSILIRAELSHPGMFIGNDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWMLPPSLTLLLSSSMVENGAGTGWTVYPPLSSGTAHAGASVDLAIFSLHLAGISSILGAVNFITTVINMRSSGITLDRLPLFVWSVVITAILLLLSLPVLAGAITMLLTDRNLNTSFFDPIGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIITQESGKKETFGTLGMIYAMLTIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQLTYSPALLWSLGFVFLFTVGGLTGVVLANSSIDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFIHWYPLLTGMVMNPSWLKAQFSMMFIGVNLTFFPQHFLGLAGMPRRYSDFPDSYLTWNIISSLGSTISLFAVIFFLFIIWESMITQRTPSFPMQLSSSIEWYHTLPPAEHTYSELPLLSSNF

Sequence caution

The sequence ABY51624.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict171in Ref. 1; ABY51624

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU352212
EMBL· GenBank· DDBJ
ABY51624.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AF380835
EMBL· GenBank· DDBJ
AAK56378.2
EMBL· GenBank· DDBJ
Genomic DNA
AF390098
EMBL· GenBank· DDBJ
AAK73349.2
EMBL· GenBank· DDBJ
mRNA
AY056596
EMBL· GenBank· DDBJ
AAL25639.1
EMBL· GenBank· DDBJ
Genomic DNA
AY056597
EMBL· GenBank· DDBJ
AAL25640.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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