B0FL75 · B0FL75_DANRE
- ProteinGap junction protein
- Genegja10a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids464 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | connexin complex | |
Molecular Function | gap junction channel activity | |
Biological Process | cell-cell signaling |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGap junction protein
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionB0FL75
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 78-100 | Helical | ||||
Sequence: WVLQIIFVSSPSLVYMGHALYQL | ||||||
Transmembrane | 153-178 | Helical | ||||
Sequence: LLRTYIIHILTRSVVEVAFIVGQYIL | ||||||
Transmembrane | 209-228 | Helical | ||||
Sequence: TIFMVFMIVIAGVSLFLNLL |
Keywords
- Cellular component
Interaction
Subunit
A connexon is composed of a hexamer of connexins.
Structure
Family & Domains
Features
Showing features for domain, coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 43-76 | Connexin N-terminal | ||||
Sequence: DVWVDEQSEFVCNTDQPGCKNVCYDQAFPISLIR | ||||||
Coiled coil | 100-144 | |||||
Sequence: LRSLEKERHRRKIQLRAELEETEPLLEEHRKLEKELRRLEEQKKM | ||||||
Domain | 167-233 | Gap junction protein cysteine-rich | ||||
Sequence: VEVAFIVGQYILYGIGLDPLYKCERVPCPNSVDCYVSRPTEKTIFMVFMIVIAGVSLFLNLLEISHL | ||||||
Region | 345-375 | Disordered | ||||
Sequence: QENQHPDSSNCSERDIRPFSSGHPGSEGHTE | ||||||
Region | 395-464 | Disordered | ||||
Sequence: DDAMESSESDFCPPNRKASFMARMPSESMSGSPSCPSTRSSESELGSLNDLPMNPPPGGGRRMSMASRWK | ||||||
Compositional bias | 419-442 | Polar residues | ||||
Sequence: PSESMSGSPSCPSTRSSESELGSL |
Sequence similarities
Belongs to the connexin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length464
- Mass (Da)52,549
- Last updated2008-02-26 v1
- Checksum1A527F30309EA47A
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
B3DJY1 | B3DJY1_DANRE | gja10a | 464 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 419-442 | Polar residues | ||||
Sequence: PSESMSGSPSCPSTRSSESELGSL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU332873 EMBL· GenBank· DDBJ | ABY53494.1 EMBL· GenBank· DDBJ | mRNA |