B0DEY8 · B0DEY8_LACBS

Function

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site, site.

165050100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site7Mg2+ 1 (UniProtKB | ChEBI)
Binding site42Mg2+ 1 (UniProtKB | ChEBI)
Active site154
Active site195Proton donor/acceptor
Binding site195Mg2+ 1 (UniProtKB | ChEBI)
Binding site197Mg2+ 1 (UniProtKB | ChEBI)
Site197Transition state stabilizer
Site285Important for catalytic activity
Binding site310Mg2+ 1 (UniProtKB | ChEBI)
Active site311Proton acceptor
Binding site311Mg2+ 1 (UniProtKB | ChEBI)
Site311Interaction with DNA substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    DNA-(apurinic or apyrimidinic site) endonuclease 2

Gene names

    • ORF names
      LACBIDRAFT_299606

Organism names

Accessions

  • Primary accession
    B0DEY8

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias370-384Polar residues
Region370-558Disordered
Compositional bias393-433Polar residues
Compositional bias434-451Pro residues
Compositional bias461-481Basic and acidic residues
Compositional bias529-556Polar residues
Domain572-633GRF-type

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    650
  • Mass (Da)
    71,848
  • Last updated
    2008-02-26 v1
  • Checksum
    C4753079469CB8D6
MRILTWNINGVRTLPQYHPWNTLKAHDDILNHLEADIICFQEMKSSRPALPKQVAVPPSYDSFFSFPIRKSGYSGVATYTRHSAVIPLKAEEGLSGVLQPKPPLTAAERISDSDNYPPNAETASIEGDLDYADLDSEGRTVILDLGLFVLINVYCPNDGNGTEERDKYKMDFHRLLEMRVVGLIKEGREVMVVGDLNACAAIIDHCEGHLMVAKGLAEGLQGEEGFWGKDSRRWMRGFLVPEDEGMPGGFMIDIVRKLWPERKGMYTCWNTKISARDSNYGTRIDYILITRGLLPWVKAADIQPLIKGSDHCPVYVDLFDEITDPTTGAVVELRRAMGLQDDGRKDPPRLAARFWDEYSGKQTQLHKFFGQKSKGSGSSDTPCPALVPSPSPIIVDDNNSATITPSSTPIPTTQTSTSGSSTTKSSPVPSSPLQQPSSSQPRPPSSSPPPVPISTKRKLVADIRSTSKKRKQREEEEKKPSQQSIASFFAKPMRKPKDSLPPASSSIKAKGKQRAPEGDVDLEEDYQFALQLSQLNEPLVPSKSQSKNSKSHGGKGTAEWTNLLAPIQPPKCIVHGELAKELTVTKQGANKGKRFFICARPVGPGYDKGRGERLREHVDPHWKCDFFKWSSEVRREMVRNGNSGADVGVS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias370-384Polar residues
Compositional bias393-433Polar residues
Compositional bias434-451Pro residues
Compositional bias461-481Basic and acidic residues
Compositional bias529-556Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS547107
EMBL· GenBank· DDBJ
EDR06754.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp