B0CYJ4 · B0CYJ4_LACBS

Function

function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.

Features

Showing features for binding site, active site.

1765100200300400500600700
TypeIDPosition(s)Description
Binding site195-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1205-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site441-443L-homocysteine (UniProtKB | ChEBI)
Binding site441-443L-methionine (UniProtKB | ChEBI)
Binding site494L-methionine (UniProtKB | ChEBI)
Binding site5715-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site609L-homocysteine (UniProtKB | ChEBI)
Binding site609L-methionine (UniProtKB | ChEBI)
Binding site651Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site653Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site675Zn2+ 1 (UniProtKB | ChEBI); catalytic
Active site704Proton donor
Binding site736Zn2+ 1 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
Molecular Functionzinc ion binding
Biological Processmethionine biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
  • EC number

Gene names

    • ORF names
      LACBIDRAFT_183094

Organism names

Accessions

  • Primary accession
    B0CYJ4

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-311Cobalamin-independent methionine synthase MetE N-terminal
Domain436-758Cobalamin-independent methionine synthase MetE C-terminal/archaeal

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    765
  • Mass (Da)
    84,730
  • Last updated
    2008-02-26 v1
  • Checksum
    EE8F54D80031AC1D
MVSSSVLGFPRIGANREVKKAVEAYWAEKFTADELTKVAADVKRASWTSVKAQGVDFIPSGEFSLYDHVLDHSAAFNVIPKRYVGLGLSPLDVYFAMGRGRQSEVVDVPASEMKKWFDSNYHFVVPEFSDETDFKLNFNKALLEFKEAQAAGVTTRPVVLGPISFLTLGKASKDAKPGFQPISLLPKLLPIYKTLLTDLKQAGAEWVQVDEPILVLDTAAALENEFATAYAELAPVAPKILLTTYFSRLDSNLTFIAKLPVAGLHIDLDRAPAQLDEVISAVKSTPIILSLGVVSGRNIWKTDFAAAIKLGQKAIDALGPDRVIVATSSSLLHTPVTLASETKLTPQQKDWFSFALEKAGEVATIAAVLSGSQDPKVAAALEENNTSIAKRREFESSSDDTVRKRVAAITDDQLERKSPFTTRREIQAKHLKLPKFPTTTIGSFPQTKEIRQARAKLGKGELTEEQYEEFIKKEIGAVVRFQEKIGLDLLVHGEPERNDMVQYFGEQLHGFVFTQNAWVQSYGSRYVRPPIIVSDVSRPGPMTVKWSSYAQSLTSKPMKGMLTGPVTILNWSFPRADVSRELQSKQLALALRDEVVDLEKAGISAIQVDEPAIREGLPLRRSDWDAYLKWAVDSFKLSTAGVTDQLQTHSHFCYSDFDDIFPSIQRLDADVISIEASKADMKLLNTFKHYGYSNQIGPGVYDIHSPRVPGGQEIKDRLKSMLDILPDSLLFVNPDCGLKTRGWKETEASLINLVEGAKWARENYA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS547094
EMBL· GenBank· DDBJ
EDR12893.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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