B0C4I0 · NDK_ACAM1
- ProteinNucleoside diphosphate kinase
- Genendk
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids149 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 9 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 57 | ATP (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 85 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 91 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 102 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 112 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Active site | 115 | Pros-phosphohistidine intermediate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | nucleoside diphosphate kinase activity | |
Biological Process | CTP biosynthetic process | |
Biological Process | GTP biosynthetic process | |
Biological Process | UTP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNucleoside diphosphate kinase
- EC number
- Short namesNDK ; NDP kinase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Acaryochloridales > Acaryochloridaceae > Acaryochloris
Accessions
- Primary accessionB0C4I0
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000080952 | 1-149 | Nucleoside diphosphate kinase | |||
Sequence: MERTFLAVKPDGVQRGLVGEIISRYEAKGFTLVGLKLMVVSRELAEQHYGEHKEKPFFSGLVDFITSGPVVAMVWEGKGVVAAARKIIGATNPLGSEPGTIRGDFGIDIGRNIIHGSDAVETAQREISLWFKSEELADWSPTLTSWIYE |
Keywords
- PTM
Interaction
Structure
Sequence
- Sequence statusComplete
- Length149
- Mass (Da)16,379
- Last updated2008-02-26 v1
- Checksum90C5936A6B69A74C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000828 EMBL· GenBank· DDBJ | ABW28723.1 EMBL· GenBank· DDBJ | Genomic DNA |