B0BQ52 · RLMC_ACTPJ
- Protein23S rRNA (uracil(747)-C(5))-methyltransferase RlmC
- GenerlmC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids391 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
Catalytic activity
- uridine747 in 23S rRNA + S-adenosyl-L-methionine = 5-methyluridine747 in 23S rRNA + S-adenosyl-L-homocysteine + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 5 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 13 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 16 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 95 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 220 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 249 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 276 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 322 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Active site | 349 | Nucleophile | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | iron ion binding | |
Molecular Function | rRNA (uridine-C5-)-methyltransferase activity | |
Biological Process | rRNA base methylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name23S rRNA (uracil(747)-C(5))-methyltransferase RlmC
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Actinobacillus
Accessions
- Primary accessionB0BQ52
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000414814 | 1-391 | 23S rRNA (uracil747-C5)-methyltransferase RlmC | ||
Structure
Family & Domains
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length391
- Mass (Da)44,117
- Last updated2008-02-26 v1
- ChecksumF9ADA9FE1693C941
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000687 EMBL· GenBank· DDBJ | ABY69687.1 EMBL· GenBank· DDBJ | Genomic DNA |