B0BMY1 · LAAT1_RAT
- ProteinLysosomal amino acid transporter 1 homolog
- GeneSlc66a1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids293 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
3.36 mM | arginine |
pH Dependence
Optimum pH is acidic with no activity detected at a pH higher that 7.0.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | lysosomal membrane | |
Cellular Component | organelle membrane | |
Molecular Function | basic amino acid transmembrane transporter activity | |
Molecular Function | L-arginine transmembrane transporter activity | |
Molecular Function | L-histidine transmembrane transporter activity | |
Molecular Function | L-lysine transmembrane transporter activity | |
Biological Process | intracellular amino acid homeostasis | |
Biological Process | L-arginine transmembrane transport | |
Biological Process | L-histidine transmembrane transport | |
Biological Process | L-lysine transmembrane transport | |
Biological Process | lysine transport |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLysosomal amino acid transporter 1 homolog
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionB0BMY1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Lysosome membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-37 | Lumenal | ||||
Sequence: MVWRTLVASNFSTCPNGSIQWIWDVFGECAQDGWDEA | ||||||
Transmembrane | 38-58 | Helical | ||||
Sequence: SVALGLVSIFCFAASTFPQYI | ||||||
Topological domain | 59-71 | Cytoplasmic | ||||
Sequence: KACKTGNMDQALS | ||||||
Transmembrane | 72-92 | Helical | ||||
Sequence: LWFLLGWIGGDSCNLIGSFLA | ||||||
Topological domain | 93-96 | Lumenal | ||||
Sequence: DQLP | ||||||
Transmembrane | 97-117 | Helical | ||||
Sequence: LQTYTAVYYVLADLLMLTLYF | ||||||
Topological domain | 118-126 | Cytoplasmic | ||||
Sequence: HYKFKKQPS | ||||||
Transmembrane | 127-147 | Helical | ||||
Sequence: LLSAPINSVLLFILGTVCITP | ||||||
Topological domain | 148-182 | Lumenal | ||||
Sequence: LLSSTDPVAVPREGFRGRTLLSVEPGNKPFTKKEV | ||||||
Transmembrane | 183-203 | Helical | ||||
Sequence: VGFVIGSASSVLYLLSRLPQI | ||||||
Topological domain | 204-214 | Cytoplasmic | ||||
Sequence: RTNFVRQSTQG | ||||||
Transmembrane | 215-235 | Helical | ||||
Sequence: ISYSLFALVMLGNTLYGLSVL | ||||||
Topological domain | 236-254 | Lumenal | ||||
Sequence: LKNPEVGQSEGSYLLHHLP | ||||||
Transmembrane | 255-275 | Helical | ||||
Sequence: WLVGSLGVLLLDTIISIQFLV | ||||||
Topological domain | 276-293 | Cytoplasmic | ||||
Sequence: YRSHDADAASEREPLLPS |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 290-291 | Abolishes lysosomal localization. | ||||
Sequence: LL → AA |
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000423746 | 1-293 | Lysosomal amino acid transporter 1 homolog | |||
Sequence: MVWRTLVASNFSTCPNGSIQWIWDVFGECAQDGWDEASVALGLVSIFCFAASTFPQYIKACKTGNMDQALSLWFLLGWIGGDSCNLIGSFLADQLPLQTYTAVYYVLADLLMLTLYFHYKFKKQPSLLSAPINSVLLFILGTVCITPLLSSTDPVAVPREGFRGRTLLSVEPGNKPFTKKEVVGFVIGSASSVLYLLSRLPQIRTNFVRQSTQGISYSLFALVMLGNTLYGLSVLLKNPEVGQSEGSYLLHHLPWLVGSLGVLLLDTIISIQFLVYRSHDADAASEREPLLPS | ||||||
Glycosylation | 10 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 34-100 | PQ-loop 1 | ||||
Sequence: WDEASVALGLVSIFCFAASTFPQYIKACKTGNMDQALSLWFLLGWIGGDSCNLIGSFLADQLPLQTY | ||||||
Domain | 191-243 | PQ-loop 2 | ||||
Sequence: SSVLYLLSRLPQIRTNFVRQSTQGISYSLFALVMLGNTLYGLSVLLKNPEVGQ | ||||||
Motif | 290-291 | Di-leucine motif | ||||
Sequence: LL |
Domain
The di-leucine motif mediates lysosomal localization.
Sequence similarities
Belongs to the laat-1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length293
- Mass (Da)32,232
- Last updated2008-02-26 v1
- Checksum357C081C690128E7
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I5Y800 | A0A8I5Y800_RAT | Slc66a1 | 310 | ||
A0A8L2QDE2 | A0A8L2QDE2_RAT | Slc66a1 | 361 |
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AABR06040567 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR06040568 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH473968 EMBL· GenBank· DDBJ | EDL80912.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CH473968 EMBL· GenBank· DDBJ | EDL80913.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
BC158607 EMBL· GenBank· DDBJ | AAI58608.1 EMBL· GenBank· DDBJ | mRNA |