B0BMT8 · B0BMT8_RAT
- ProteinELAV-like protein
- GeneElavl4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids373 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Publications for B0BMT8
Expression of HuD protein is essential for initial phase of neuronal differentiation in rat pheochromocytoma PC12 cells.
- CategoriesExpression, Function
Downregulation of P2Y2 and HuD during the development of the enteric nervous system in fetal rats with anorectal malformations.
- Annotationdownregulation of P2Y2 and HuD may partly be related to the development of the enteric nervous system in anorectal malformations embryos.
- CategoriesExpression
- SourceGeneRif: 432358
Axonal localization of neuritin/CPG15 mRNA is limited by competition for HuD binding.
- AnnotationThe data indicate that endogenous Nrn1 and Gap43 mRNAs compete for binding to HuD for their axonal localization and activity of the Nrn1 3'UTR.
- CategoriesFunction, Subcellular Location
- SourceGeneRif: 432358
The impact of HuD protein on the intestinal nervous system in the terminal rectum of animal models of congenital anorectal malformation.
- Annotationthe HuD protein is abnormally expressed in the nerve plexuses of the intestinal wall of the terminal rectum of ARM embryonic rats which suggests that HuD may participate in the development and maturation of the ENS in ARM embryonic rats.
- CategoriesFunction, Sequences, Expression
- SourceGeneRif: 432358
Different motif requirements for the localization zipcode element of beta- actin mRNA binding by HuD and ZBP1.
- AnnotationBoth ZBP1 and HuD bind the zipcode element in rat beta-actin mRNA's 3' UTR. Differences between HuD and ZBP1 were observed in their binding preference to the element.
- CategoriesFunction
- SourceGeneRif: 432358
Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic Branch Variability through the Capture of Ca2+/Calmodulin-dependent Protein Kinase II alpha (CaMKIIalpha) mRNAs by the RNA-binding Protein HuD.
- AnnotationmTOR inhibition reduces HuD binding and promotes deadenylation of CaMKIIalpha mRNA.
- CategoriesFunction
- SourceGeneRif: 432358
HuD interacts with Bdnf mRNA and is essential for activity-induced BDNF synthesis in dendrites.
- Annotationa direct effect of HuD on regulating translation of dendritic Bdnf mRNAs
- CategoriesFunction, Subcellular Location
Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1.
- AnnotationmTORC1 activity regulation of mRNA stability and high affinity HuD-target mRNA degradation mediates the bidirectional expression of dendritic Kv1.1 ion channels.
- CategoriesFunction
- SourceGeneRif: 432358
Melatonin-mediated insulin synthesis during endoplasmic reticulum stress involves HuD expression in rat insulinoma INS-1E cells.
- AnnotationMelatonin directly influences intracellular biosynthesis and extracellular secretion of insulin under endoplasmic reticulum (ER)stress via HuD expression in rat insulinoma INS-1E cells.
- CategoriesFunction, Expression
PKC activation during training restores mushroom spine synapses and memory in the aged rat.
- CategoriesExpression, Phenotypes & Variants, Subcellular Location
Protein kinase C stimulates HuD-mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in culture.
- AnnotationPKC may play an important role in neuronal differentiation and synaptogenesis via stimulating HuD-mediated mRNA stability and inhibiting CARM1 in hippocampal neurons
- CategoriesFunction, PTM / Processing, Interaction, Function
HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens.
- AnnotationThe predominant expression of REST4 HuB/C/D and nPTB in post-mitotic fiber cells together with miR-124 expression in vertebrate lenses was shown.
- CategoriesSequences, Expression
- SourceGeneRif: 432358
- PubMed
- Europe PMC
- Mol Vis 16:2301-2316 ()
Mapped toAUF1 and Hu proteins in the developing rat brain: implication in the proliferation and differentiation of neural progenitors.
- Annotationfindings indicated a specific developmental pattern of expression of HuD in the postnatal cerebellum; data suggest HuD might be involved in the transition of neural progenitors into early neuroblasts
- CategoriesFunction, Expression
- SourceGeneRif: 432358
Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain.
- CategoriesExpression
- SourceRGD: 1560027
Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons.
- AnnotationPost-transcriptional regulation of neuronal mRNAs by HuD RNA binding proteins mediates protein synthesis-dependent changes in synaptic plasticity.
- CategoriesFunction, Expression
- SourceGeneRif: 432358
Coordinated expression of HuD and GAP-43 in hippocampal dentate granule cells during developmental and adult plasticity.
- CategoriesPhenotypes & Variants
- SourceRGD: 1560027
Neuron-specific Hu proteins sub-cellular localization in primary sensory neurons.
- AnnotationPart of a family of RNa-binding proteins found in sensory neurons.
- CategoriesSubcellular Location
- SourceGeneRif: 432358
HuD distribution changes in response to heat shock but not neurotrophic stimulation.
- CategoriesSubcellular Location
- SourceRGD: 1560027
CARM1 regulates proliferation of PC12 cells by methylating HuD.
- Annotationa novel mechanism of arginine methylation of HuD by coactivator-associated arginine methyltransferase 1 (CARM1) that affected mRNA turnover
- CategoriesFunction
- SourceGeneRif: 432358
Dendritic localization of the RNA-binding protein HuD in hippocampal neurons: association with polysomes and upregulation during contextual learning.
- AnnotationHuD plays a role in synaptic plasticity mechanisms stabilizing mRNAs associated with ribosomes both in the soma and dendrites of hippocampal neurons.
- CategoriesFunction, Subcellular Location, Expression, Subcellular Location
GAP-43 mRNA in growth cones is associated with HuD and ribosomes.
- CategoriesSubcellular Location
- SourceRGD: 1560027
Increase of the RNA-binding protein HuD and posttranscriptional up- regulation of the GAP-43 gene during spatial memory.
- CategoriesSubcellular Location
- SourceRGD: 1560027
Increased expression and localization of the RNA-binding protein HuD and GAP-43 mRNA to cytoplasmic granules in DRG neurons during nerve regeneration.
- AnnotationHuD is involved in the upregulation of GAP-43 expression observed at early stages of peripheral nerve regeneration.
- CategoriesExpression, Phenotypes & Variants