A9ZSY2 · TRET1_APILI
- ProteinFacilitated trehalose transporter Tret1
- GeneTret1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids502 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Moderate-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
9.42 mM | trehalose |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | sugar transmembrane transporter activity | |
Molecular Function | trehalose transmembrane transporter activity | |
Biological Process | trehalose transport |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameFacilitated trehalose transporter Tret1
- Short namesAmTRET1
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Apoidea > Anthophila > Apidae > Apis
Accessions
- Primary accessionA9ZSY2
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-38 | Cytoplasmic | ||||
Sequence: MGVENTKQTMSSQNIKPAKDSDDVLHTQFKEVKRSPMR | ||||||
Transmembrane | 39-59 | Helical; Name=1 | ||||
Sequence: YTMQLLAALAVSMASLMIGYS | ||||||
Topological domain | 60-83 | Extracellular | ||||
Sequence: SSYTSPALVSMRDNTTATFEVTMD | ||||||
Transmembrane | 84-104 | Helical; Name=2 | ||||
Sequence: MAMWIGSIMPLSALIGGIIGG | ||||||
Topological domain | 105-120 | Cytoplasmic | ||||
Sequence: PCIEYIGRRNTILSTA | ||||||
Transmembrane | 121-141 | Helical; Name=3 | ||||
Sequence: LPFLAGWLFIALATNVAMILV | ||||||
Topological domain | 142-144 | Extracellular | ||||
Sequence: GRS | ||||||
Transmembrane | 145-165 | Helical; Name=4 | ||||
Sequence: ICGFCVGVASLSLPVYLGESI | ||||||
Topological domain | 166-172 | Cytoplasmic | ||||
Sequence: QPEVRGS | ||||||
Transmembrane | 173-193 | Helical; Name=5 | ||||
Sequence: LGLLPTVFGNSGILMCFTAGM | ||||||
Topological domain | 194-199 | Extracellular | ||||
Sequence: YLAWRN | ||||||
Transmembrane | 200-220 | Helical; Name=6 | ||||
Sequence: LALLGACIPIIFLILMFLIPE | ||||||
Topological domain | 221-282 | Cytoplasmic | ||||
Sequence: TPRWYISKGKIKEARKSLQWLRGKTADISEELDSIQKMHIESERIATEGALIELFRKNHIKP | ||||||
Transmembrane | 283-303 | Helical; Name=7 | ||||
Sequence: VFISLGLMFFQQFSGINAVIF | ||||||
Topological domain | 304-319 | Extracellular | ||||
Sequence: YTVQIFKDSGSTVDEN | ||||||
Transmembrane | 320-340 | Helical; Name=8 | ||||
Sequence: LSTIIVGLVNFISTFVAAMII | ||||||
Topological domain | 341-346 | Cytoplasmic | ||||
Sequence: DRLGRK | ||||||
Transmembrane | 347-367 | Helical; Name=9 | ||||
Sequence: MLLYISSILMCITLFTFGTFF | ||||||
Topological domain | 368-376 | Extracellular | ||||
Sequence: YVKELMDVT | ||||||
Transmembrane | 377-397 | Helical; Name=10 | ||||
Sequence: AFGWIPLMSLIVYVIGFSFGF | ||||||
Topological domain | 398-410 | Cytoplasmic | ||||
Sequence: GPIPWLMMGEILP | ||||||
Transmembrane | 411-433 | Helical; Name=11 | ||||
Sequence: VKIRGTAASVATAFNWSCTFVVT | ||||||
Topological domain | 434-446 | Extracellular | ||||
Sequence: KTYEDLVLHIGPY | ||||||
Transmembrane | 447-467 | Helical; Name=12 | ||||
Sequence: GTFWLFGTLVAVAFIFVIICV | ||||||
Topological domain | 468-502 | Cytoplasmic | ||||
Sequence: PETRGRSLEEIERRFAGPVRRTSAIANLKPMPITI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000395539 | 1-502 | Facilitated trehalose transporter Tret1 | |||
Sequence: MGVENTKQTMSSQNIKPAKDSDDVLHTQFKEVKRSPMRYTMQLLAALAVSMASLMIGYSSSYTSPALVSMRDNTTATFEVTMDMAMWIGSIMPLSALIGGIIGGPCIEYIGRRNTILSTALPFLAGWLFIALATNVAMILVGRSICGFCVGVASLSLPVYLGESIQPEVRGSLGLLPTVFGNSGILMCFTAGMYLAWRNLALLGACIPIIFLILMFLIPETPRWYISKGKIKEARKSLQWLRGKTADISEELDSIQKMHIESERIATEGALIELFRKNHIKPVFISLGLMFFQQFSGINAVIFYTVQIFKDSGSTVDENLSTIIVGLVNFISTFVAAMIIDRLGRKMLLYISSILMCITLFTFGTFFYVKELMDVTAFGWIPLMSLIVYVIGFSFGFGPIPWLMMGEILPVKIRGTAASVATAFNWSCTFVVTKTYEDLVLHIGPYGTFWLFGTLVAVAFIFVIICVPETRGRSLEEIERRFAGPVRRTSAIANLKPMPITI | ||||||
Glycosylation | 73 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 319 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Structure
Family & Domains
Sequence similarities
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length502
- Mass (Da)55,517
- Last updated2008-02-26 v1
- ChecksumC43F96A09779542E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB369549 EMBL· GenBank· DDBJ | BAF96743.1 EMBL· GenBank· DDBJ | mRNA |