A9YWT8 · PRTS_PHOAZ

Function

function

Metalloprotease involved in the inhibition of insect antibacterial peptides. Reduces the antibacterial activity of G.mellonella hemolymph by 50%. Reduces the antibacterial activity of cecropin A by 80% and completely inhibits cecropin B.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Activity regulation

Inhibited by 8 mM 1,10-phenanthroline, but not by EDTA or PMSF.

pH Dependence

Optimum pH is 7.0.

Temperature Dependence

Optimum temperature is 50 degrees Celsius. Active from 10 to 80 degrees Celsius.

Features

Showing features for binding site, active site.

137150100150200250300350
TypeIDPosition(s)Description
Binding site169Zn2+ (UniProtKB | ChEBI); catalytic
Active site170
Binding site173Zn2+ (UniProtKB | ChEBI); catalytic
Binding site193Zn2+ (UniProtKB | ChEBI); catalytic
Active site273Proton donor

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

Gene names

    • Name
      prtS

Organism names

Accessions

  • Primary accession
    A9YWT8

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, signal.

TypeIDPosition(s)Description
ChainPRO_0000397930?-371Protease PrtS
Signal1-?

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region352-371Disordered

Sequence similarities

Belongs to the peptidase M4 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    371
  • Mass (Da)
    41,773
  • Last updated
    2008-02-05 v1
  • Checksum
    D69F180F84871D5B
MQIQNNNYKGLIPPYILQNIYKNTSESEKDNVLMTLNHTQSLMLDSVIKTSDSIDNTDDEVVSDTLHRSIYDAKNETKLPGTLVRDEGDPDNGDVAVDNAYKYLEATYNFYKEVFNRNSLDDKGMKLIATVHYGKEYMNAYWGRGQMVFGDGDGKVFNNFTTSIDVIGHELSHGVIEKTADLIYFFQSGALNESIADVFGSLVRQHYLKQKADEASWVVGEELLAKGIKGVGIRSMKEPGKAYDDPLLGKNPQPGHMDDFKDYPIYRDNGGVHVNSGIPNKAFYNLAIKLGGYAWEKAGKIWYNTLLDKDLARDTTFLSFAKLTVKHARDLFDEDVEKATIDSWKEVGIKVKEEDKDKGKDEGKDKAETKV

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict57in Ref. 2; AA sequence
Sequence conflict62in Ref. 2; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU307118
EMBL· GenBank· DDBJ
ABY26041.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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