A9YDN5 · A9YDN5_CALMU

Function

function

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentmelanosome
Molecular Functiontransferrin receptor activity
Biological Processintracellular iron ion homeostasis
Biological Processreceptor internalization
Biological Processtransferrin transport

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Transferrin receptor protein 1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Sigmodontinae > Calomys

Accessions

  • Primary accession
    A9YDN5

Subcellular Location

Cell membrane
; Single-pass type II membrane protein
Melanosome
Membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane65-87Helical

Keywords

PTM/Processing

Post-translational modification

Stearoylated.

Keywords

Interaction

Subunit

Homodimer; disulfide-linked.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain228-312PA
Domain388-578Peptidase M28
Domain638-749Transferrin receptor-like dimerisation

Sequence similarities

Belongs to the peptidase M28 family. M28B subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    760
  • Mass (Da)
    85,708
  • Last updated
    2008-02-05 v1
  • Checksum
    355A65CD5D5C05C4
MMDQARSAISNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENVDNMKASVRKPRRFNGRLCFGTIAVLIFFLIGFMIGYLGYCKRIEQKDCARLAEMETINSQNLQPEEDIPKSSRLYWADLKKLLSEKLDAIDFTDTIKQLSQNTYTPREAGSQKDENLAYYIENQFHDLKLSKVWRDEHYVKLQVKSSVAQNSVTIINASGGSYPLENPAGYVAYSKAAEVTGKLVHANFGTKKDFENLNYAVNGSLVIVRAGEITFAEKVANAQSFNAIGVLIYMDKNKFPVVKADLSLFGHAHLGTGDPYTPGFPSFNHTQFPPSQSSGLPSIPVQTISRETADKLFQKMEGNCPPGWNVDSSCKLELTSDKTVKLVVRNELKETRILNIFGVIKGFEEPDRYIVVGAQRDSWGPGAAKSSVGTALLLKLAQTFSDMVLRGGFKPSRSIIFASWTAGDFGAVGATEWLEGYLSSLHLKAFTYINLDKVVLGTSKFKVSASPLLYTLIEKTMQDVKHPIDGKSLYRDSNWISNVKKLSFDNAAFPFLAYSGIPAVSFSFCEDEDYPYLDTTLDTYDLLIQKVPQLNKMVRVAAEVAGQFIIKLTHEIELNLDYDMYNNRILSFVRDLNQFRADIREMGLSLQWLYSARGDYFRATSRLTSDFHNAEKTNRFVMREINDRIMKVEYHFLSPYVSPRESPFRHIFWGYGSHTLSALMENLKLRQTNISAFNETLFRNQLALASWTIQGVANALSGDIWNIDNEF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU164541
EMBL· GenBank· DDBJ
ABX89905.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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