A9YDN4 · A9YDN4_CALCL
- ProteinTransferrin receptor protein 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids760 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | external side of plasma membrane | |
Cellular Component | melanosome | |
Molecular Function | transferrin receptor activity | |
Biological Process | intracellular iron ion homeostasis | |
Biological Process | receptor internalization | |
Biological Process | transferrin transport |
Keywords
- Molecular function
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameTransferrin receptor protein 1
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Sigmodontinae > Calomys
Accessions
- Primary accessionA9YDN4
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type II membrane protein
Membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 65-87 | Helical | ||||
Sequence: LCFGTIAVVIFFLIGFMIGYLGY |
Keywords
- Cellular component
PTM/Processing
Post-translational modification
Stearoylated.
Keywords
- PTM
Interaction
Subunit
Homodimer; disulfide-linked.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 228-305 | PA | ||||
Sequence: VTGKLVHANFGTKKDFENLNYAVNGSLVIVRAGEITFAEKVANAQSLNAIGVLIYMDKNKFPVVKADLSLFGHAHLGT | ||||||
Domain | 388-578 | Peptidase M28 | ||||
Sequence: NIFGVIKGFEEPDRYIVVGAQRDSWGPGAAKSSVGTALLLKLAQTFSDMVLRGGFKPSRSIIFASWTAGDFGAVGATEWLEGYLSSLHLKAFTYINLDKVVLGTSKFKVSASPLLYTLIEKTMQDVKHPIDGKSLYRDSNWISNVKKLSFDNAAFPFLAYSGIPAVSFSFCEDEDYPYLDTILDTYDLLIQ | ||||||
Domain | 638-749 | Transferrin receptor-like dimerisation | ||||
Sequence: SLQWLYSARGDYFRATSRLTSDFHNAEKTNRFVMREINDRIMKVEYHFLSPYVSPRESPFRHIFWGYGSHTLSALMENLKLRQTNISAFNETLFRNQLALASWTIQGVANAL |
Sequence similarities
Belongs to the peptidase M28 family. M28B subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length760
- Mass (Da)85,657
- Last updated2008-02-05 v1
- Checksum66B4FDA341969F51