A9VA99 · A9VA99_MONBE

Function

function

Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Functionhistone H3K79 methyltransferase activity
Molecular Functionhistone H3K79 trimethyltransferase activity
Biological ProcessDNA damage checkpoint signaling
Biological ProcessDNA repair
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone-lysine N-methyltransferase, H3 lysine-79 specific
  • EC number
  • Alternative names
    • Histone H3-K79 methyltransferase

Gene names

    • ORF names
      MONBRDRAFT_34214

Organism names

Accessions

  • Primary accession
    A9VA99

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, compositional bias, coiled coil.

Type
IDPosition(s)Description
Region1-87Disordered
Domain131-428DOT1
Region433-549Disordered
Compositional bias476-500Basic and acidic residues
Compositional bias523-549Polar residues
Coiled coil579-613
Region709-919Disordered
Compositional bias741-766Polar residues
Compositional bias779-834Polar residues
Compositional bias889-919Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    919
  • Mass (Da)
    99,082
  • Last updated
    2008-02-05 v1
  • Checksum
    529CA3D95C972687
MAASAEAEVSQSKPSPLKDQAGPVQPRPAGLTPGNPVQAVVEEAASPCASSPQAPSSAPNSHRRPVGGRIGRVHLGQPGRRVPDEEDVEAIPGGSRELGITEDWFDVPPLFPPVDTTQTHLAILSPNPKGPPMLYQWPFTHMTDSSYDAGFELLNSMNHIVKLCALPVPDTWADDIVACAKPGTEFASLSKVVEAFNAAMRVYHKSVGEQAERLICPTDLCEHIMNMTYSRAVTDPALLNRYKGWTAEVYGEFTSKMISDVIANSNVQPDDTFVDLGSGVGQVVLQVALEGRARTSFGIEKQDIPAEYAKCGAYELVKDNFLQPQYAERITNTSVVFLNNFAFGTKVNQQLCRMFENCQAGTRLISSISLRKSDFTITARTLNDLGCILTMRKLCYRGQGVSWTARPFSYYVQTVNHQYLDQFFSKGEPVQVPFENEVGDDDDDANPDRTGTSHSGAPVRDNSDDEEDNDEEAEDQSAGAAGHHKTDAVGKGHSGAERDGKAAAGTRPGSTKRSKGASRRRDRQSSQQSSAPPSSSSGKVAAGDDSASQRLVRTLTRAVAGLERRYPSGRTLRAARHQLRALHQERSVLRQHRREYEQQLQQHNQTVAAALTQRRQQLNESLGLDSKTDTRLTAAAAGLLHTFVCRGGQSATSSAANAQQSVEHIRLWTKPLQQAQAVHERLIAALRMHGQAPVADALQRTPWALPRDLCASNEHSPTRATNGHVPVQEASAGKAGPTGPHQSARRSSDQNGSASSQVQSAQTRGLEATPDRYAGPLSSAETSPASTSSHSAGKRDLSGQREATNGTEHTSQAQIAGRRESSSTGTSPTSSLAKLLGAEPSHRSGHRQGQQRPIARAREMRPPGGARPGLSSSSKRPLSSNGEPAPQVPDPKRTKDLENASSDNALERKQKCHGPETSN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias476-500Basic and acidic residues
Compositional bias523-549Polar residues
Compositional bias741-766Polar residues
Compositional bias779-834Polar residues
Compositional bias889-919Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH991573
EMBL· GenBank· DDBJ
EDQ85503.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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