A9V196 · SLX1_MONBE

Function

function

Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentSlx1-Slx4 complex
Molecular Function5'-flap endonuclease activity
Molecular Functioncrossover junction DNA endonuclease activity
Molecular Functionmetal ion binding
Biological Processdouble-strand break repair via homologous recombination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Structure-specific endonuclease subunit SLX1 homolog
  • EC number

Gene names

    • ORF names
      8836

Organism names

Accessions

  • Primary accession
    A9V196

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003837651-420Structure-specific endonuclease subunit SLX1 homolog

Interaction

Subunit

Forms a heterodimer with a member of the SLX4 family.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias, zinc finger.

TypeIDPosition(s)Description
Domain19-106GIY-YIG
Region237-306Disordered
Compositional bias248-270Polar residues
Compositional bias279-297Basic and acidic residues
Region311-330Disordered
Zinc finger348-405SLX1-type

Sequence similarities

Belongs to the SLX1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    420
  • Mass (Da)
    45,633
  • Last updated
    2008-02-05 v1
  • Checksum
    38A61AD8A9F6C94A
MAGGYIARVNMKGHYLSWSSDNTYPWQNIQPTQNTKLLGLQDIGFTTDPVRRLRQHNSEIGGGAVRTTRAKGSWDMAAIVYGFPNKVAALRFEWAWQHPLKSRRLRDAVRSDLPASRAAQMQLTAKLHTLAAMLYTVPWSDQPLTLCWLQPDIADKWSNIWQRHCQCQSALPPFLTTRSGNLQDPLFQLNNAAAAASTIQRAALAADHHAWRLAAAAQAQAPDFFTGLGRLDLAAPSVEESGAGPHPSSCSVPPSTGSSAAPTPGALAPQPTKQNKFGVDPRLDSDDRDDNHQFESPDNHEAAAVNVDVVDDSADDGTTDGNEDGPDDVAPHQEVTARHVHGAIGETCGHCHQSVYQELCIVCLNATCTYRAHLLCAAQAAVHPLGQSSPSETRLVPLRHSCPRCAHQAHWASWIAEVTL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias248-270Polar residues
Compositional bias279-297Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH991553
EMBL· GenBank· DDBJ
EDQ88769.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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