A9UWE3 · A9UWE3_MONBE

Function

function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site, active site.

135450100150200250300350
TypeIDPosition(s)Description
Binding site25-26NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site77NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site125-127NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site176-177NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site177K+ (UniProtKB | ChEBI)
Binding site179K+ (UniProtKB | ChEBI)
Active site182Thioimidate intermediate
Binding site182K+ (UniProtKB | ChEBI)
Active site184Proton donor/acceptor
Binding site185K+ (UniProtKB | ChEBI)
Binding site215-217GMP (UniProtKB | ChEBI)
Binding site238-239GMP (UniProtKB | ChEBI)
Binding site264-266GMP (UniProtKB | ChEBI)
Binding site265NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site281-282NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGMP reductase complex
Molecular FunctionGMP reductase activity
Molecular Functionmetal ion binding
Biological Processpurine nucleobase metabolic process
Biological Processpurine nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GMP reductase
  • EC number
  • Short names
    GMPR
  • Alternative names
    • Guanosine 5'-monophosphate oxidoreductase
      (Guanosine monophosphate reductase
      )

Gene names

    • ORF names
      MONBRDRAFT_16151

Organism names

Accessions

  • Primary accession
    A9UWE3

Proteomes

Subcellular Location

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-335IMP dehydrogenase/GMP reductase

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    354
  • Mass (Da)
    38,360
  • Last updated
    2008-02-05 v1
  • Checksum
    D0010334CD9E787F
MRIEEDIKLDFKDVLIRPKRSTLKSRSEVTLERTYKFLHSKQEWTGVPIIAANMDTTGTFETAAVLAEQGLITAASKHYSSSAWVEQPAEVVKHMAVSSGISDSDFERLSETLKTRPDIPFICLDVANGYSEAFVQFVRRVRQAFPNKTIMAGNVVTQEMVEELILSGADIVKVGIGPGSVCTTRKQTGVGYPQLSAVIECADAAHGLGGLVISDGGCTCPGDVSKAFGAGADFVMLGGMLAGHDESAGELIERDGKFYKQFYGMSSDTAMKKYHGSVAEYRSSEGKTIELPYRGPIKATILDVLGGLRSSCTYVGASTLKEISKRTTFIRVTQQVCPAVHVLCSCLFSHTCLR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH991547
EMBL· GenBank· DDBJ
EDQ90548.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp