A9RVK2 · M3K1B_PHYPA
- ProteinMitogen-activated protein kinase kinase kinase 1b
- GeneMEKK1b
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids764 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
The CERK1, MEKK1a/b, MKK1a/b/c and MPK4a/b proteins are involved in pathogen defense. The pathway induces rapid growth inhibition, cell wall depositions and accumulation of defense-related transcripts. This protein is required for responses to chitin and acts redundantly with MEKK1a.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | MAP kinase kinase kinase activity | |
Molecular Function | protein serine kinase activity | |
Biological Process | defense response | |
Biological Process | MAPK cascade | |
Biological Process | response to chitin |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase kinase kinase 1b
- EC number
- Short namesPpMEKK1b
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Bryophyta > Bryophytina > Bryopsida > Funariidae > Funariales > Funariaceae > Physcomitrium
Accessions
- Primary accessionA9RVK2
Proteomes
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Reduced chitin-induced MPK phosphorylation. Exhibits chitin-induced cell wall-associated depositions comparable to wild-type. Reduced accumulation of PAL4 and CHS transcripts in response to chitin. Double deletion mutant MEKK1a/MEKK1b does not phosphorylate MPK and is unable to induce the depositions in response to chitin. The growth of the double mutant is inhibited within 1 minute after chitin exposure as in wild-type.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000443377 | 1-764 | Mitogen-activated protein kinase kinase kinase 1b | |||
Sequence: MVEERGSSRSSRGGSWGSGEDGGSSHGGKGVPKLSRTVAKKIHKYDVSADHSDYEDDGSVHSTSSSGSRRNPLSKSIIQQQSFRVGANFEEDLKTLYELIGVSKPADLAISASDWQSRGKSIAYSQPLSSPSLSQEHGEASHSNDLKPSIIDFRSEAPAASPRELPVAPVKLDAHERMTYRSDYVNSQPQNHYGRKNSPSQRSPPPESFPAFDSSPSRLGREGYGLHRMQSDPVMPTLGALSPLGTGNAHPESAGSTATRRWSFDLVPGNHEGDYANMSQVVRDNLPSAAVAMPKNGLVRRSPIIRDPNRSNSSVSNPYAQRQYPNLAEEAESSAKPESSAIPDSSAMPELPAKLESTAVPELSAKPESNAKPESEPEQDSSVEARTEHYGSVRKSKIPSALIIDKFEEPSIVSTGRSPGVVSKRPPWDTWFKGDFIGSGTFGSVYEGIDNNGMFFAVKEVSLKDQGKVGQEAIKQLEHEIALLSDIQHPNIVQYLGTERDDEKLYIFLELVSKGSLASLYKKYYFVYDQVRAYTKQILSGLKYLHDRKIIHRDIKCANILVDTNGVVKLADFGMAKQVDKLGLLKSFMGSAHWMAPEVVNPKRQYNFLADIWSLGCTVLEMATGDAPFGELECHSVLWKVGNGEGPLIPDDLEDEMKDFISKCLEVTVGNRPTCDMLLTHPFITGEPMTGPVKLVPMPELSTISEERSIDVSESPSIATSSQSGSSPSVAGDAVSPASVAVRPRSMRTLRSEFSMSSPESIAS |
Proteomic databases
Expression
Induction
Up-regulated in response to chitosan.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-81 | Disordered | ||||
Sequence: MVEERGSSRSSRGGSWGSGEDGGSSHGGKGVPKLSRTVAKKIHKYDVSADHSDYEDDGSVHSTSSSGSRRNPLSKSIIQQQ | ||||||
Compositional bias | 39-58 | Basic and acidic residues | ||||
Sequence: AKKIHKYDVSADHSDYEDDG | ||||||
Compositional bias | 59-81 | Polar residues | ||||
Sequence: SVHSTSSSGSRRNPLSKSIIQQQ | ||||||
Compositional bias | 120-139 | Polar residues | ||||
Sequence: KSIAYSQPLSSPSLSQEHGE | ||||||
Region | 120-260 | Disordered | ||||
Sequence: KSIAYSQPLSSPSLSQEHGEASHSNDLKPSIIDFRSEAPAASPRELPVAPVKLDAHERMTYRSDYVNSQPQNHYGRKNSPSQRSPPPESFPAFDSSPSRLGREGYGLHRMQSDPVMPTLGALSPLGTGNAHPESAGSTATR | ||||||
Compositional bias | 181-202 | Polar residues | ||||
Sequence: RSDYVNSQPQNHYGRKNSPSQR | ||||||
Region | 325-348 | Disordered | ||||
Sequence: PNLAEEAESSAKPESSAIPDSSAM | ||||||
Region | 360-392 | Disordered | ||||
Sequence: VPELSAKPESNAKPESEPEQDSSVEARTEHYGS | ||||||
Compositional bias | 369-392 | Basic and acidic residues | ||||
Sequence: SNAKPESEPEQDSSVEARTEHYGS | ||||||
Domain | 431-684 | Protein kinase | ||||
Sequence: WFKGDFIGSGTFGSVYEGIDNNGMFFAVKEVSLKDQGKVGQEAIKQLEHEIALLSDIQHPNIVQYLGTERDDEKLYIFLELVSKGSLASLYKKYYFVYDQVRAYTKQILSGLKYLHDRKIIHRDIKCANILVDTNGVVKLADFGMAKQVDKLGLLKSFMGSAHWMAPEVVNPKRQYNFLADIWSLGCTVLEMATGDAPFGELECHSVLWKVGNGEGPLIPDDLEDEMKDFISKCLEVTVGNRPTCDMLLTHPFI | ||||||
Compositional bias | 706-733 | Polar residues | ||||
Sequence: EERSIDVSESPSIATSSQSGSSPSVAGD | ||||||
Region | 706-764 | Disordered | ||||
Sequence: EERSIDVSESPSIATSSQSGSSPSVAGDAVSPASVAVRPRSMRTLRSEFSMSSPESIAS | ||||||
Compositional bias | 750-764 | Polar residues | ||||
Sequence: LRSEFSMSSPESIAS |
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length764
- Mass (Da)83,151
- Last updated2018-02-28 v2
- Checksum577DA7E6C41FEED9
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 39-58 | Basic and acidic residues | ||||
Sequence: AKKIHKYDVSADHSDYEDDG | ||||||
Compositional bias | 59-81 | Polar residues | ||||
Sequence: SVHSTSSSGSRRNPLSKSIIQQQ | ||||||
Compositional bias | 120-139 | Polar residues | ||||
Sequence: KSIAYSQPLSSPSLSQEHGE | ||||||
Compositional bias | 181-202 | Polar residues | ||||
Sequence: RSDYVNSQPQNHYGRKNSPSQR | ||||||
Compositional bias | 369-392 | Basic and acidic residues | ||||
Sequence: SNAKPESEPEQDSSVEARTEHYGS | ||||||
Compositional bias | 706-733 | Polar residues | ||||
Sequence: EERSIDVSESPSIATSSQSGSSPSVAGD | ||||||
Compositional bias | 750-764 | Polar residues | ||||
Sequence: LRSEFSMSSPESIAS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS544920 EMBL· GenBank· DDBJ | EDQ77074.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |