A9QPI2 · A9QPI2_METI4
- ProteinBifunctional protein FolD
- GenefolD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids298 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Catalytic activity
- (6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H+
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 167-169 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 196 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 237 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | L-histidine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional protein FolD
Including 2 domains:
- Recommended nameMethylenetetrahydrofolate dehydrogenase
- EC number
- Recommended nameMethenyltetrahydrofolate cyclohydrolase
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Verrucomicrobiota > Methylacidiphilae > Methylacidiphilales > Methylacidiphilaceae > Methylacidiphilum (ex Ratnadevi et al. 2023)
Accessions
- Primary accessionA9QPI2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 7-121 | Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic | |||
Domain | 124-291 | Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding | |||
Sequence similarities
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length298
- Mass (Da)32,770
- Last updated2008-02-05 v1
- MD5 ChecksumF362000EFAC4425D54125CC70470CB91
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU223898 EMBL· GenBank· DDBJ | ABX56640.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP000975 EMBL· GenBank· DDBJ | ACD82861.1 EMBL· GenBank· DDBJ | Genomic DNA |