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A9QPI2 · A9QPI2_METI4

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site167-169NADP+ (UniProtKB | ChEBI)
Binding site196NADP+ (UniProtKB | ChEBI)
Binding site237NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD
    • Ordered locus names
      Minf_0806

Organism names

Accessions

  • Primary accession
    A9QPI2

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-121Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain124-291Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    298
  • Mass (Da)
    32,770
  • Last updated
    2008-02-05 v1
  • MD5 Checksum
    F362000EFAC4425D54125CC70470CB91
MEEAQLLDGRLVAEEIHKETREAVQRLRRKGILPCVVFIRVGNHPPSELYVRMKQKKAQEVGIQSEVIALPEDVTQQEVLESLDRLNQDPSIHGILVQLPLPKHLSEKKIALAIDPRKDIDGFHPLNLGKMLLGEKDCFYPCTPLGIQELLKRYQIETEGKEVVILGRSNIVGKPLAALFLQKSKYANATVTVVHSLSQNIKEHCQKADILVAALGKAHFVTKDFVKPKAVVVDVGVSRIADPSSPQGFKIAGDVDFAEIKKIASWITPNPGGVGPMTIAMLLANTVKAAELSLGHPF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU223898
EMBL· GenBank· DDBJ
ABX56640.1
EMBL· GenBank· DDBJ
Genomic DNA
CP000975
EMBL· GenBank· DDBJ
ACD82861.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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