A9QPF5 · A9QPF5_METI4
- ProteinFormate dehydrogenase
- Genehpr
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids398 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the NAD+-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
Catalytic activity
- formate + NAD+ = CO2 + NADH
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 123 | substrate | |||
Binding site | 147 | substrate | |||
Binding site | 148 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 202-203 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 222 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 257-261 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 283 | NAD+ (UniProtKB | ChEBI) | |||
Site | 285 | Important for catalytic activity | |||
Binding site | 309 | NAD+ (UniProtKB | ChEBI) | |||
Site | 333 | Important for catalytic activity | |||
Binding site | 333-336 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 381 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | formate dehydrogenase (NAD+) activity | |
Molecular Function | NAD binding | |
Molecular Function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | |
Biological Process | formate catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFormate dehydrogenase
- EC number
- Short namesFDH
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Verrucomicrobiota > Methylacidiphilae > Methylacidiphilales > Methylacidiphilaceae > Methylacidiphilum (ex Ratnadevi et al. 2023)
Accessions
- Primary accessionA9QPF5
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 64-363 | D-isomer specific 2-hydroxyacid dehydrogenase catalytic | |||
Domain | 156-334 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding | |||
Sequence similarities
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length398
- Mass (Da)43,654
- Last updated2008-02-05 v1
- ChecksumC009C441DB0AE7E6
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU223871 EMBL· GenBank· DDBJ | ABX56613.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP000975 EMBL· GenBank· DDBJ | ACD83377.1 EMBL· GenBank· DDBJ | Genomic DNA |