A9NE96 · FOLD_ACHLI

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site159-161NADP+ (UniProtKB | ChEBI)
Binding site184NADP+ (UniProtKB | ChEBI)
Binding site225NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD
    • Ordered locus names
      ACL_0033

Organism names

Accessions

  • Primary accession
    A9NE96

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003405731-277Bifunctional protein FolD

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    277
  • Mass (Da)
    30,601
  • Last updated
    2008-02-05 v1
  • Checksum
    4608A3632F5ECC66
MLLDGRKTADILNEALRVKVQYLTKKPKLEIILIGNDEASKSYVKGKLNTASNLGMEVHINYLDEAIDQLSVEALIQKLNTDKGVHGILLQLPIPKHLDSDYLISLIDYKKDVDGFHTMNQGLLFQKKDGIRPATPLGIMMLLDFYNIPIEGKHVVIIGRSQIVGAPLSKMFLDRNATVTITHSKTKNLPSITKQADILVAAIGKPKFVTKDMVKVGAVVVDVGINRVDKKLVGDVDFEHVEPIASYITPVPKGVGPMTICALAHNLYALYLKQEKE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000896
EMBL· GenBank· DDBJ
ABX80676.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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