A9NE96 · FOLD_ACHLI
- ProteinBifunctional protein FolD
- GenefolD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids277 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Catalytic activity
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP+ = (6R)-5,10-methenyltetrahydrofolate + NADPH
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | L-histidine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional protein FolD
Including 2 domains:
- Recommended nameMethylenetetrahydrofolate dehydrogenase
- EC number
- Recommended nameMethenyltetrahydrofolate cyclohydrolase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Mycoplasmatota > Mollicutes > Acholeplasmatales > Acholeplasmataceae > Acholeplasma
Accessions
- Primary accessionA9NE96
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000340573 | 1-277 | Bifunctional protein FolD | |||
Sequence: MLLDGRKTADILNEALRVKVQYLTKKPKLEIILIGNDEASKSYVKGKLNTASNLGMEVHINYLDEAIDQLSVEALIQKLNTDKGVHGILLQLPIPKHLDSDYLISLIDYKKDVDGFHTMNQGLLFQKKDGIRPATPLGIMMLLDFYNIPIEGKHVVIIGRSQIVGAPLSKMFLDRNATVTITHSKTKNLPSITKQADILVAAIGKPKFVTKDMVKVGAVVVDVGINRVDKKLVGDVDFEHVEPIASYITPVPKGVGPMTICALAHNLYALYLKQEKE |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length277
- Mass (Da)30,601
- Last updated2008-02-05 v1
- Checksum4608A3632F5ECC66
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000896 EMBL· GenBank· DDBJ | ABX80676.1 EMBL· GenBank· DDBJ | Genomic DNA |