A9JPE4 · ATMA_ASPFL

  • Protein
    Terpene cyclase atmA
  • Gene
    atmA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

Aflatrem synthesis protein A; part of the ATM2 gene cluster that mediates the biosynthesis of aflatrem, a tremorgenic mycotoxin with acute neurotoxic effects (PubMed:19801473, PubMed:2867895).
Synthesis of geranylgeranyl diphosphate (GGPP) by AtmG (a GGPP synthase) precedes condensation of GGPP with indole 3-glycerol phosphate, followed by epoxidation and cyclization by AtmM (a FAD-dependent monooxygenase) and AtmC (a prenyltransferase) to produce paspaline (PubMed:19801473).
AtmB is also essential for paspaline production, but its exact role has not been identified yet (PubMed:19801473).
AtmP, a cytochrome P450 monooxygenase, subsequently converts paspaline to 13-desoxypaxilline via PC-M6 by removal of the C-30 methyl group and oxidation at C-10 (PubMed:19801473).
AtmQ, a cytochrome P450 monooxygenase, then catalyzes the oxidation of 13-desoxypaxilline, first at C-7 to produce paspalicine and then at C-13 to form paspalinine (PubMed:19801473).
Finally, AtmD prenylates paspalinine to form aflatrem (PubMed:19801473).
The role of atmA in the aflatrem biosynthesis is still unknown (PubMed:19801473).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Functionisomerase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Terpene cyclase atmA
  • EC number
  • Alternative names
    • Aflatrem synthesis protein A

Gene names

    • Name
      atmA

Organism names

  • Taxonomic identifier
  • Strain
    • NRRL 6541
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati

Accessions

  • Primary accession
    A9JPE4

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane9-29Helical
Transmembrane84-104Helical
Transmembrane113-133Helical
Transmembrane162-182Helical
Transmembrane195-215Helical
Transmembrane233-253Helical
Transmembrane291-311Helical
Transmembrane333-353Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004361201-366Terpene cyclase atmA

Expression

Induction

The onset of expression occurs at 48-hour-old stationary cultures and the steady-state levels correlates with the onset of aflatrem biosynthesis at 108 hours (PubMed:19801473).

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    366
  • Mass (Da)
    40,985
  • Last updated
    2008-02-05 v1
  • Checksum
    D57459A7367927C2
MDSVLRYVFLLLAMTSFYMMYISLFNNGFFNLLSHQLATRALPGESDIALLSEYTGLKAFDGILESIVIFFWPISQGHHVGLSLTGLSFSGGMVGIWMIVVVHICRIRSFTRGMVITLIVGIAQQAVGPGIVIPCYFALTSRARPPNKNLHLTGTYSTSNHGLVVSMIMSYIFPLVIMSLPAPAMISPHSKQQVIAAWQGWPVYFVIIMTTHHLFINRGHRKEASARRQVLSVYHFGFACSCLCHMAWLSAFVASKIQSLSQSSNFWYLCPYGVAFPLLNQPAQRLGALEAGLFTFLQWDYCVAAAATMVWSTDRYIQECHRAELEIDKFRLILRLLGWILIDGPSATAVRLIWESEGPSYLQNPN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AM921700
EMBL· GenBank· DDBJ
CAP53940.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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