A9CB88 · PKG3_ADES1

Function

function

Involved in viral genome packaging through its interaction with packaging proteins 1 and 2. After proteolytic cleavage by adenovirus protease, L1 52/55k protein is removed from the capsid during viral maturation.

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nucleus
Biological Processviral DNA genome packaging
Biological Processviral release from host cell

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Packaging protein 3
  • Alternative names
    • L1-52/55 kDa protein
    • Packaging protein 52K

Gene names

    • Name
      L1

Organism names

Accessions

  • Primary accession
    A9CB88

Proteomes

Subcellular Location

Host nucleus
Note: Nuclear protein present in empty capsids and assembly intermediates.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004259211-322Packaging protein 3

Post-translational modification

Cleaved at different sites by the viral protease during virion maturation.

Keywords

Expression

Induction

Expressed in the early phase and late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Part of the genome packaging complex composed of packaging proteins 1, 2 and 3; this complex specifically binds to the packaging sequence on the left end of viral genomic DNA and performs packaging of the viral genome. Interacts with hexon-linking protein IIIa; this interaction is required to promote correct genome packaging.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-24Disordered
Region1-127Interaction with packaging protein 1

Sequence similarities

Belongs to the adenoviridae packaging protein 3 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    322
  • Mass (Da)
    36,790
  • Last updated
    2008-01-15 v1
  • Checksum
    5125CEACC3A071D1
MHPILKNIRSQPDQGRAEEHNPELHCGIAGTGGLEEQLRSKQREDRFHKACPPAVDLNRDDTQLYGEGERDLRLKSSACVQLDRTPVTPEDFVPDDMGSRAIRQMEAAKLVRNGQHTRDVERWQHDTYCSHLTQLLVRPLTSLGVMYLADFLNTFVELPPNHTLTMQLVTIINHTSEPTLRRLLKDIGEKDAEGHLKNEWLLQLLSIIEMIFKDEPSERARLTALLTVTNEVALNFSKKASGGNYPTTDRLSKTLTYFRRMIVALLALAESLGCYTNNYCARKPEKRCRTQVEPSDESYMFSLKGALEAPESDEEEEEWIRD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ106414
EMBL· GenBank· DDBJ
ABA47238.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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