A8XW88 · KAPC1_CAEBR
- ProteincAMP-dependent protein kinase catalytic subunit
- Genekin-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids374 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. May play a role in the regulation of neuromuscular junctions.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Activity regulation
Binding of cAMP to kin-2 regulatory subunits induces dissociation of the heterotetramer. The released catalytic subunits are active and able to phosphorylate their substrates.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cAMP-dependent protein kinase complex | |
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | AMP-activated protein kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | cAMP-dependent protein kinase activity | |
Molecular Function | protein serine kinase activity | |
Biological Process | protein kinase A signaling |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namecAMP-dependent protein kinase catalytic subunit
- EC number
- Short namesPKA C
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionA8XW88
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000432402 | 1-374 | cAMP-dependent protein kinase catalytic subunit | |||
Sequence: MLKFLKPKSSDEGSSKDNKSAASLKEFLDKAREDFKQRWENPAQNTACLDDFDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIEKIVSGKVKFPSHFSNELKDLLKNLLQVDLTKRYGNLKNGVADIKNHKWFGSTDWIAIYQRKIKPPSFSNGEPKGRLFEALYARVDGPADTRHFVEEVQEPTQFVIASTCQLPELFEDF |
Expression
Developmental stage
Expressed at low levels in the embryo. Expression increases after hatching and during larval stages and is followed by a decrease in adults (at protein level).
Interaction
Subunit
Heterotetramer composed of two regulatory subunits and two catalytic subunits.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-22 | Disordered | ||||
Sequence: MLKFLKPKSSDEGSSKDNKSAA | ||||||
Domain | 52-305 | Protein kinase | ||||
Sequence: FDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIEKIVSGKVKFPSHFSNELKDLLKNLLQVDLTKRYGNLKNGVADIKNHKWF |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length374
- Mass (Da)43,045
- Last updated2008-01-15 v1
- Checksum0DD389B0D230300B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HE601474 EMBL· GenBank· DDBJ | CAP36907.1 EMBL· GenBank· DDBJ | Genomic DNA |