A8SMG2 · SMI10_BOVIN

  • Protein
    Sperm-associated microtubule inner protein 10
  • Gene
    SPMIP10
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme, which is required for flagellum beating (PubMed:37327785).
May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella (PubMed:37327785).
Involved in the regulation of sperm motility (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoskeleton
Cellular Componentmotile cilium
Biological Processflagellated sperm motility

Names & Taxonomy

Protein names

  • Recommended name
    Sperm-associated microtubule inner protein 10
  • Alternative names
    • Testis-expressed protein 43

Gene names

    • Name
      SPMIP10
    • Synonyms
      C5orf48, TEX43

Organism names

  • Taxonomic identifier
  • Strain
    • Crossbred X Angus
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A8SMG2

Proteomes

Organism-specific databases

Subcellular Location

Note: Localizes at the ribbon and inner junction (IJ) between A- and B-tubules of the DMTs.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003218231-133Sperm-associated microtubule inner protein 10

Proteomic databases

Expression

Tissue specificity

Expressed in sperm.

Gene expression databases

Interaction

Subunit

Microtubule inner protein component of sperm flagellar doublet microtubules.

Protein-protein interaction databases

Family & Domains

Sequence

  • Sequence status
    Complete
  • Length
    133
  • Mass (Da)
    15,181
  • Last updated
    2008-02-26 v2
  • Checksum
    38EA56A5D7F8D9DC
MASGKDTCPILPKLTNNCSDENSDKLANKCEIHLPRFSLKQGMIPRHYVMPWKQNMKFRNVNLKHAEACGIHAGPLEDSLFLDHSERLCHGEDRKVVLKKGPPEIKIADMPLHSPLSRYQSTVISHGFRRRLI

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAA9TMI8A0AAA9TMI8_BOVINSPMIP1024

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EH372678
EMBL· GenBank· DDBJ
-mRNA No translation available.
BC126782
EMBL· GenBank· DDBJ
AAI26783.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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