A8QFF6 · SPAST_BRUMA

Function

function

Severs microtubules, probably in an ATP-dependent fashion.

Caution

Lacks the conserved MIT domain, which is one of the features of the spastin family.

Catalytic activity

  • n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.
    EC:5.6.1.1 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site.

145450100150200250300350400450
TypeIDPosition(s)Description
Binding site218-225ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmicrotubule
Cellular Componentperinuclear region of cytoplasm
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionisomerase activity
Molecular Functionmicrotubule severing ATPase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable spastin homolog Bm1_53365
  • EC number

Gene names

    • ORF names
      Bm1_53365

Organism names

Accessions

  • Primary accession
    A8QFF6

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003671301-454Probable spastin homolog Bm1_53365

Interaction

Subunit

Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Interacts with microtubules (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the AAA ATPase family. Spastin subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    454
  • Mass (Da)
    51,150
  • Last updated
    2008-01-15 v1
  • Checksum
    CC1366536E4FB80A
MLHPQKLEQQNYETFNKAYLKSKQLVTEGVSIDEISSNNDEQRKRIAMEKYRMGIEYFEKALKISPDKVYPEKRSEVITHREAMKRNLEATKGRLSDLEKMFPSKGNRNLQHRPVQFVSPSISKPQTAQLSSRPISSEKKNINYSNARTRSNLLKGVDDKFGGPLLNEILNQDDVKMSDIIGAETAKRALEETVILPTVNPSLFSGLRQPAQGILLFGPPGNGKTLLARAVAGECGSTMFLNVSAASLTSKWVGDAEKIVRALFQIARNGQPTIIFIDEIDSILCERNEKETEVSRRMKTEFLIQMDGMLSSKDDRLLVIGATNRPEELDSAILRRFPKRILIDVPNAAARLKLIMSLLEKTKTSFDLGLTQRQILAEWTHGYSNSDLVALCREAAMVPIRDLSRKDIKNLVSTELRPITLRDFEIAMKAIKPSTNERMLQKLRKYAATAGQSD

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P6BTY0A0A1P6BTY0_BRUMABma-spas-1478
A0A1D5BL00A0A1D5BL00_BRUMABma-spas-1454

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS239470
EMBL· GenBank· DDBJ
EDP29011.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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