A8QFF6 · SPAST_BRUMA
- ProteinProbable spastin homolog Bm1_53365
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids454 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Severs microtubules, probably in an ATP-dependent fashion.
Catalytic activity
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | microtubule | |
Cellular Component | perinuclear region of cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | isomerase activity | |
Molecular Function | microtubule severing ATPase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable spastin homolog Bm1_53365
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Spiruromorpha > Filarioidea > Onchocercidae > Brugia
Accessions
- Primary accessionA8QFF6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000367130 | 1-454 | Probable spastin homolog Bm1_53365 | |||
Sequence: MLHPQKLEQQNYETFNKAYLKSKQLVTEGVSIDEISSNNDEQRKRIAMEKYRMGIEYFEKALKISPDKVYPEKRSEVITHREAMKRNLEATKGRLSDLEKMFPSKGNRNLQHRPVQFVSPSISKPQTAQLSSRPISSEKKNINYSNARTRSNLLKGVDDKFGGPLLNEILNQDDVKMSDIIGAETAKRALEETVILPTVNPSLFSGLRQPAQGILLFGPPGNGKTLLARAVAGECGSTMFLNVSAASLTSKWVGDAEKIVRALFQIARNGQPTIIFIDEIDSILCERNEKETEVSRRMKTEFLIQMDGMLSSKDDRLLVIGATNRPEELDSAILRRFPKRILIDVPNAAARLKLIMSLLEKTKTSFDLGLTQRQILAEWTHGYSNSDLVALCREAAMVPIRDLSRKDIKNLVSTELRPITLRDFEIAMKAIKPSTNERMLQKLRKYAATAGQSD |
Interaction
Subunit
Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Interacts with microtubules (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the AAA ATPase family. Spastin subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length454
- Mass (Da)51,150
- Last updated2008-01-15 v1
- ChecksumCC1366536E4FB80A
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P6BTY0 | A0A1P6BTY0_BRUMA | Bma-spas-1 | 478 | ||
A0A1D5BL00 | A0A1D5BL00_BRUMA | Bma-spas-1 | 454 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS239470 EMBL· GenBank· DDBJ | EDP29011.1 EMBL· GenBank· DDBJ | Genomic DNA |