A8NEF7 · A8NEF7_COPC7
- ProteinAutophagy-related protein 9
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids858 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)
- a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
- a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | autophagosome | |
Cellular Component | phagophore assembly site membrane | |
Biological Process | autophagy of mitochondrion | |
Biological Process | lipid transport | |
Biological Process | protein localization to phagophore assembly site |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAutophagy-related protein 9
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Agaricales > Agaricineae > Psathyrellaceae > Coprinopsis
Accessions
- Primary accessionA8NEF7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Golgi apparatus membrane ; Multi-pass membrane protein
Preautophagosomal structure membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 238-257 | Helical | ||||
Sequence: LLFSGVTLLFFILFTAFYLW | ||||||
Transmembrane | 456-478 | Helical | ||||
Sequence: ILMRFVAFIAGSFAAVLLLATLI | ||||||
Transmembrane | 494-512 | Helical | ||||
Sequence: VLFYLGVFGGILTVARGMI | ||||||
Transmembrane | 560-581 | Helical | ||||
Sequence: LLIFIQEIVSVVTTPFVLWFSL |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-192 | Disordered | ||||
Sequence: MFNPMSRSRTYQGYMRADALPEEEDEHGSSGEDIDLESGSSPNAPRQKRSAKSQGKRKVSWDGNASEMNVLRPNIQKDDKKHEGESSEDDEVPQSFMIEATAGAAARQPTRHRGESDSGSSRSAMKRGQPLYSTSARSVPPILPTVAPHVSIPPKPSELDVEEDNMETPRLARGASASGSSNGDSSRQPKPM | ||||||
Compositional bias | 34-49 | Polar residues | ||||
Sequence: IDLESGSSPNAPRQKR | ||||||
Compositional bias | 73-89 | Basic and acidic residues | ||||
Sequence: PNIQKDDKKHEGESSED | ||||||
Compositional bias | 121-140 | Polar residues | ||||
Sequence: SRSAMKRGQPLYSTSARSVP | ||||||
Compositional bias | 174-188 | Polar residues | ||||
Sequence: GASASGSSNGDSSRQ | ||||||
Compositional bias | 763-787 | Polar residues | ||||
Sequence: QNSVHLGPSPSRSAQGASNATGETG | ||||||
Region | 763-839 | Disordered | ||||
Sequence: QNSVHLGPSPSRSAQGASNATGETGSSHEAEKEEERSTVHNEIGLGDSYVDGAKRPVKPYVSEGADEEEEELEDGGV | ||||||
Compositional bias | 788-803 | Basic and acidic residues | ||||
Sequence: SSHEAEKEEERSTVHN |
Sequence similarities
Belongs to the ATG9 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length858
- Mass (Da)96,214
- Last updated2010-08-10 v2
- Checksum00161B751CC487EA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 34-49 | Polar residues | ||||
Sequence: IDLESGSSPNAPRQKR | ||||||
Compositional bias | 73-89 | Basic and acidic residues | ||||
Sequence: PNIQKDDKKHEGESSED | ||||||
Compositional bias | 121-140 | Polar residues | ||||
Sequence: SRSAMKRGQPLYSTSARSVP | ||||||
Compositional bias | 174-188 | Polar residues | ||||
Sequence: GASASGSSNGDSSRQ | ||||||
Compositional bias | 763-787 | Polar residues | ||||
Sequence: QNSVHLGPSPSRSAQGASNATGETG | ||||||
Compositional bias | 788-803 | Basic and acidic residues | ||||
Sequence: SSHEAEKEEERSTVHN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AACS02000002 EMBL· GenBank· DDBJ | EAU88703.2 EMBL· GenBank· DDBJ | Genomic DNA |