A8NEF7 · A8NEF7_COPC7

Function

function

Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentautophagosome
Cellular Componentphagophore assembly site membrane
Biological Processautophagy of mitochondrion
Biological Processlipid transport
Biological Processprotein localization to phagophore assembly site

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Autophagy-related protein 9

Gene names

    • ORF names
      CC1G_01076

Organism names

Accessions

  • Primary accession
    A8NEF7

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasmic vesicle membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Golgi apparatus membrane
; Multi-pass membrane protein
Preautophagosomal structure membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane238-257Helical
Transmembrane456-478Helical
Transmembrane494-512Helical
Transmembrane560-581Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-192Disordered
Compositional bias34-49Polar residues
Compositional bias73-89Basic and acidic residues
Compositional bias121-140Polar residues
Compositional bias174-188Polar residues
Compositional bias763-787Polar residues
Region763-839Disordered
Compositional bias788-803Basic and acidic residues

Sequence similarities

Belongs to the ATG9 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    858
  • Mass (Da)
    96,214
  • Last updated
    2010-08-10 v2
  • Checksum
    00161B751CC487EA
MFNPMSRSRTYQGYMRADALPEEEDEHGSSGEDIDLESGSSPNAPRQKRSAKSQGKRKVSWDGNASEMNVLRPNIQKDDKKHEGESSEDDEVPQSFMIEATAGAAARQPTRHRGESDSGSSRSAMKRGQPLYSTSARSVPPILPTVAPHVSIPPKPSELDVEEDNMETPRLARGASASGSSNGDSSRQPKPMRGLDEYERALWNWVNVYNLDAFLQEVYMYYEGKGIYSIALSRGLNLLFSGVTLLFFILFTAFYLWQIYSYVMDVLRLVDMYNFYTHLLKIPDSDIQTISWAEVVRRIGAIRQENPITAISSTGSKSKDNNTSTAKLDAHDVANRIMRQENYLIALFNKDLLDLRVPLPGFLNRFVTPEKGKGKVLTQALEWNLRFCLMGYLFDSHGRQYQKDPGSISGRRYTSYAQWKFREFNELPHIFTRRLDESYPLANVYMGQFPNEKMTILMRFVAFIAGSFAAVLLLATLIDPDIFLNFEITPHRTVLFYLGVFGGILTVARGMIPEENRVFDPELLMNEVIAYTHYMPDDWKGELHSKRVNQEFGELFKMKLLIFIQEIVSVVTTPFVLWFSLPDCAPAIVDFFREFTVHVDGRGYVCSFAEFNFERHGNVKFGAPAKAKDNRMISNDGKMEKSFLNFKAANPDWQPTDPSGSLYLNRMANLNANLHQQLSRRRQQQEQAGYAGDRDLSATVHFAPDSYDRALRQSQHAALTRRRGLGNSIMTMSMLNAAGPEGASSVYAGDLLMARTAVLGDSQNSVHLGPSPSRSAQGASNATGETGSSHEAEKEEERSTVHNEIGLGDSYVDGAKRPVKPYVSEGADEEEEELEDGGVLGLLTQIYGRRDGPTVGMP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias34-49Polar residues
Compositional bias73-89Basic and acidic residues
Compositional bias121-140Polar residues
Compositional bias174-188Polar residues
Compositional bias763-787Polar residues
Compositional bias788-803Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AACS02000002
EMBL· GenBank· DDBJ
EAU88703.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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