A8NAI8 · A8NAI8_COPC7

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site, site.

160950100150200250300350400450500550600
Type
IDPosition(s)Description
Binding site7Mg2+ 1 (UniProtKB | ChEBI)
Binding site42Mg2+ 1 (UniProtKB | ChEBI)
Active site158
Active site200Proton donor/acceptor
Binding site200Mg2+ 1 (UniProtKB | ChEBI)
Binding site202Mg2+ 1 (UniProtKB | ChEBI)
Site202Transition state stabilizer
Site288Important for catalytic activity
Binding site313Mg2+ 1 (UniProtKB | ChEBI)
Active site314Proton acceptor
Binding site314Mg2+ 1 (UniProtKB | ChEBI)
Site314Interaction with DNA substrate

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionlyase activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    DNA-(apurinic or apyrimidinic site) endonuclease 2

Gene names

    • ORF names
      CC1G_05939

Organism names

Accessions

  • Primary accession
    A8NAI8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias373-402Polar residues
Region373-596Disordered
Compositional bias420-460Polar residues
Compositional bias469-506Polar residues
Compositional bias507-531Basic and acidic residues
Compositional bias539-567Polar residues
Domain574-609GRF-type

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    609
  • Mass (Da)
    67,423
  • Last updated
    2008-01-15 v1
  • Checksum
    C2B6F8636C6ADB01
MRLLTWNINGVRTLPQYHPWNTLKTFDDILNHLESDIICFQEMKSGRKLLTQEVAVPPSFDSFFSFPIKKTGYSGVATYTRSKVAVPLKAEEGLSGILQPKPPLAPEERISNYATYPPNLLDDDMHDADDDRLDYKNLDSEGRAIVVDMGLFVLINTYCPNDGTGTEEREAFKMDYHRLLETRVRGLIEKEKREVIVVGDLNACAAVIDHCEGELMIKKGQAMGLEGEEGFWGKEYRRWIRDWLVKEDGTGGTLVDITRKLWPDREGMYTCWNTKISARETNYGTRIDFILVTPGLVPWIKASDTLPNIKGSDHCPVYADFHDSIVDPSTGKTIHLADVLGASKRDGKIPDPPRIAAKNWEEFSGKQTSLQQFFKGSAKKPASNSTSDTPSGTPSLRPKDSLTRKPSSPDPPLQLPEQNVSDVARPSVEASSSASPITVDPKADITASASSNTTKRKLVGDYTSQPKKLKKAASASGSSSTKKLTKNGQSSIASFFSQPSTATKASGSRKGKEKGRDVEMVPDEDEDYKLALLLSQEQGQEPFLPSSQSSQPETQERSKQQWTSLLAPIQPPKCKAHGEPAKEYTVNKPGPNKGKRFFICSRQVSCRDS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias373-402Polar residues
Compositional bias420-460Polar residues
Compositional bias469-506Polar residues
Compositional bias507-531Basic and acidic residues
Compositional bias539-567Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AACS02000007
EMBL· GenBank· DDBJ
EAU90023.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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