A8N936 · DNLI4_COPC7
- ProteinDNA ligase 4
- GeneLIG4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1025 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.
Catalytic activity
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 289 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 291 | N6-AMP-lysine intermediate | ||||
Sequence: K | ||||||
Binding site | 291 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 292 | ATP (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 296 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 349 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 349 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 387 | ATP (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 447 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 447 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 452 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 469 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 471 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | DNA ligase IV complex | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA ligase (ATP) activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA biosynthetic process | |
Biological Process | DNA ligation involved in DNA repair | |
Biological Process | DNA recombination | |
Biological Process | double-strand break repair via classical nonhomologous end joining | |
Biological Process | nucleotide-excision repair, DNA gap filling |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA ligase 4
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Agaricales > Agaricineae > Psathyrellaceae > Coprinopsis
Accessions
- Primary accessionA8N936
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000333259 | 1-1025 | DNA ligase 4 | |||
Sequence: MMQPTPAPSSAPGSPQRTQAEPEMETPSYPQPPQNVGTAPFSVLVKLFEKLATERKQERRRKLLDAWFRHWRREKGFDLYPVLRLLLPQKDRDRAVYGLKEKNLAKTYIKLIPLGMRDPDAIRLLNWKKPTERDKSSGDFPQVLCEVVSKRSSVIEGTLTIDELNEILDDIAKNMGKSDVQSKILRRIYNNSTADEQRWIIRIILKDMNISVKETTVFAVFHPDAQDLYNTCSDLKKVAWELWDPSRRLNAKDKEIQIFHAFAPMLCKRPTRKIEETVKAMGGSKFIIEEKLDGERMQLHKRGNEYFYCSRKGKDYTYLYGKHIGAGSLTPFIDSAFDSRIDDIILDGEMLVWDPVSERNLPFGTLKTAALDRSKKENNPRPCFKVFDLLYLNGMSLLDKTVKFRKNNLRHCIKPIPGRIEFVEEYQGETANDIRKRMEQVMENRGEGLVIKHPKAKYILNGRNTDWIKVKPEYMDNMGETVDVLVVAGNYGSGKRGGGVSTLICAVMDDRRPDSDDEPKYSSFVRIGTGLSFADYVWVRSKPWKVWDPKNPPEFLQTAKKGQEDKGDVYLEPEDSFILKVKAAEITPSDQYHMGFTMRFPRALAIRDDLSIADCMTATEVFESLKSERKRKMEDDAGITTKKRKTTVKKVALLPEYSGPNLKKVAVKTDIFNGMKFVVFSDPKSRTGEADKKELMKTIHANGGTCSQIVNKNSEAIVIYGGSITPYDLKLVIDKGIHDVIKPSWITDSVTLGEPAPFKKKYFFHATEERKYADEYNEDDGEEEGAVPSADEQERDVKSGTVEPGSETEDEDEEQAPEIKEEQDGELHEWLKVDDRKSPALPAHDEEDSVTEDDSDNADVADEEEPDLDDWFQVKGETEDEGAGALATASRHRETTPDVDGDVKMGESEEAMDYDPDVIFKHLCFYLDSPANAQRHGMATRPKYEAAITKSFEEVEKLIKDNGGKIVDLDEPKLTHVVLDKRDDSRRVELMKRTSKPRRRHLVLSDYIEACIDEGTLLDEEGESF |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-36 | Disordered | ||||
Sequence: MMQPTPAPSSAPGSPQRTQAEPEMETPSYPQPPQNV | ||||||
Compositional bias | 12-36 | Polar residues | ||||
Sequence: PGSPQRTQAEPEMETPSYPQPPQNV | ||||||
Domain | 667-763 | BRCT 1 | ||||
Sequence: VKTDIFNGMKFVVFSDPKSRTGEADKKELMKTIHANGGTCSQIVNKNSEAIVIYGGSITPYDLKLVIDKGIHDVIKPSWITDSVTLGEPAPFKKKYF | ||||||
Region | 773-904 | Disordered | ||||
Sequence: ADEYNEDDGEEEGAVPSADEQERDVKSGTVEPGSETEDEDEEQAPEIKEEQDGELHEWLKVDDRKSPALPAHDEEDSVTEDDSDNADVADEEEPDLDDWFQVKGETEDEGAGALATASRHRETTPDVDGDVK | ||||||
Compositional bias | 788-805 | Basic and acidic residues | ||||
Sequence: PSADEQERDVKSGTVEPG | ||||||
Compositional bias | 806-820 | Acidic residues | ||||
Sequence: SETEDEDEEQAPEIK | ||||||
Compositional bias | 821-846 | Basic and acidic residues | ||||
Sequence: EEQDGELHEWLKVDDRKSPALPAHDE | ||||||
Compositional bias | 847-870 | Acidic residues | ||||
Sequence: EDSVTEDDSDNADVADEEEPDLDD | ||||||
Domain | 915-1025 | BRCT 2 | ||||
Sequence: DPDVIFKHLCFYLDSPANAQRHGMATRPKYEAAITKSFEEVEKLIKDNGGKIVDLDEPKLTHVVLDKRDDSRRVELMKRTSKPRRRHLVLSDYIEACIDEGTLLDEEGESF |
Sequence similarities
Belongs to the ATP-dependent DNA ligase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,025
- Mass (Da)116,801
- Last updated2008-05-20 v2
- ChecksumB216FFD40932868C
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 12-36 | Polar residues | ||||
Sequence: PGSPQRTQAEPEMETPSYPQPPQNV | ||||||
Compositional bias | 788-805 | Basic and acidic residues | ||||
Sequence: PSADEQERDVKSGTVEPG | ||||||
Compositional bias | 806-820 | Acidic residues | ||||
Sequence: SETEDEDEEQAPEIK | ||||||
Compositional bias | 821-846 | Basic and acidic residues | ||||
Sequence: EEQDGELHEWLKVDDRKSPALPAHDE | ||||||
Compositional bias | 847-870 | Acidic residues | ||||
Sequence: EDSVTEDDSDNADVADEEEPDLDD |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AACS02000007 EMBL· GenBank· DDBJ | EFI27358.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |