A8N783 · A8N783_COPC7
- ProteinFormate dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids374 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the NAD+-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
Catalytic activity
- formate + NAD+ = CO2 + NADH
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 106 | substrate | |||
Binding site | 130 | substrate | |||
Binding site | 185-186 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 206 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 241-245 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 267 | NAD+ (UniProtKB | ChEBI) | |||
Site | 269 | Important for catalytic activity | |||
Binding site | 293 | NAD+ (UniProtKB | ChEBI) | |||
Site | 322 | Important for catalytic activity | |||
Binding site | 322-325 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | formate dehydrogenase (NAD+) activity | |
Molecular Function | NAD binding | |
Molecular Function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | |
Biological Process | formate catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFormate dehydrogenase
- EC number
- Short namesFDH
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Agaricales > Agaricineae > Psathyrellaceae > Coprinopsis
Accessions
- Primary accessionA8N783
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 55-350 | D-isomer specific 2-hydroxyacid dehydrogenase catalytic | |||
Domain | 140-311 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding | |||
Sequence similarities
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length374
- Mass (Da)40,873
- Last updated2010-08-10 v2
- ChecksumEA9171AD734CF2AA
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AACS02000003 EMBL· GenBank· DDBJ | EAU91058.2 EMBL· GenBank· DDBJ | Genomic DNA |