A8MX76 · CAN14_HUMAN

  • Protein
    Calpain-14
  • Gene
    CAPN14
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Calcium-regulated non-lysosomal thiol-protease.

Features

Showing features for active site, binding site.

168450100150200250300350400450500550600650
TypeIDPosition(s)Description
Active site101
Active site254
Active site278
Binding site570Ca2+ (UniProtKB | ChEBI)
Binding site572Ca2+ (UniProtKB | ChEBI)
Binding site574Ca2+ (UniProtKB | ChEBI)
Binding site576Ca2+ (UniProtKB | ChEBI)
Binding site581Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncalcium ion binding
Molecular Functioncalcium-dependent cysteine-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Calpain-14
  • EC number
  • Alternative names
    • Calcium-activated neutral proteinase 14 (CANP 14)

Gene names

    • Name
      CAPN14

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A8MX76
  • Secondary accessions
    • B3KRU9

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

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The viewer provides 770 variants from UniProt as well as other sources including ClinVar and dbSNP.

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Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003413731-684Calpain-14

Proteomic databases

PTM databases

Expression

Tissue specificity

Not expressed in tissues tested.

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain43-336Calpain catalytic
Region337-503Domain III
Region504-517Linker
Region518-683Domain IV
Domain557-592EF-hand 1
Domain586-621EF-hand 2
Domain651-684EF-hand 3

Sequence similarities

Belongs to the peptidase C2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

A8MX76-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    684
  • Mass (Da)
    79,568
  • Last updated
    2008-06-10 v2
  • Checksum
    6627B859E4F375A9
MSLWPPFRCRWKLAPRYSRRASPQQPQQDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHSGEKILENGLVEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRKRKPLLAIGFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRKHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQDGKGIYLQKPEWMMMALYS

A8MX76-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F1LLU4F1LLU4_HUMANCAPN14143

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0342681-176in isoform 2
Alternative sequenceVSP_034269177-184in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK092257
EMBL· GenBank· DDBJ
BAG52511.1
EMBL· GenBank· DDBJ
mRNA
AC015980
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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