IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE FA CORE COMPLEX, IDENTIFICATION IN THE BRAFT COMPLEX, INTERACTION WITH FANCM AND CENPS, SUBCELLULAR LOCATION, DNA-BINDING, FUNCTION
IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE FA CORE COMPLEX, INTERACTION WITH FANCM AND CENPS, SUBCELLULAR LOCATION, DNA-BINDING, FUNCTION
The MHF complex which is a heterotetramer that comprises two MHF1-MHF2 heterodimers is remodeled by FANCM to favor recognition of branched DNA over dsDNA.
MHF prefers branched DNA over dsDNA because it engages two duplex arms. MHF engages DNA forks or various four-way junctions independent of the junction-site structure. The DNA-binding interface of MHF is important for cellular resistance to DNA damage.
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