A8KAH1 · A8KAH1_HUMAN
- ProteinPhosphatidylserine synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids473 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + cholineThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism.
Phospholipid metabolism; phosphatidylserine biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | L-serine-phosphatidylethanolamine phosphatidyltransferase activity | |
Biological Process | phosphatidylserine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylserine synthase
- EC number
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA8KAH1
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 36-57 | Helical | ||||
Sequence: FFYRPHTITLLSFTIVSLMYFA | ||||||
Transmembrane | 69-88 | Helical | ||||
Sequence: IWRGILSVIFFFLIISVLAF | ||||||
Transmembrane | 100-121 | Helical | ||||
Sequence: LWRMVFGLSVLCFLFLVFLLFL | ||||||
Transmembrane | 188-207 | Helical | ||||
Sequence: LCWTISITWELTELFFMHLL | ||||||
Transmembrane | 219-240 | Helical | ||||
Sequence: ILDILLCNGGGIWLGMVVCRFL | ||||||
Transmembrane | 283-300 | Helical | ||||
Sequence: SFQRVAGVYLFMIIWQLT | ||||||
Transmembrane | 320-342 | Helical | ||||
Sequence: SWGRILFIGGITAPTVRQYYAYL | ||||||
Transmembrane | 354-372 | Helical | ||||
Sequence: CWVFGVIGFLEAIVCIKFG | ||||||
Transmembrane | 384-406 | Helical | ||||
Sequence: VVLWLLCVAFTTFLCLYGMIWYA |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 430-455 | Basic and acidic residues | ||||
Sequence: WHHRKGTKGSEDSPPKHAGNNESHSS | ||||||
Region | 430-473 | Disordered | ||||
Sequence: WHHRKGTKGSEDSPPKHAGNNESHSSRRRNRHSKSKVTNGVGKK | ||||||
Compositional bias | 456-473 | Basic residues | ||||
Sequence: RRRNRHSKSKVTNGVGKK |
Sequence similarities
Belongs to the phosphatidyl serine synthase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length473
- Mass (Da)55,468
- Last updated2007-12-04 v1
- Checksum5A825CA65BEE86A4
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 430-455 | Basic and acidic residues | ||||
Sequence: WHHRKGTKGSEDSPPKHAGNNESHSS | ||||||
Compositional bias | 456-473 | Basic residues | ||||
Sequence: RRRNRHSKSKVTNGVGKK |