A8KAH1 · A8KAH1_HUMAN

  • Protein
    Phosphatidylserine synthase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.

Catalytic activity

Pathway

Lipid metabolism.
Phospholipid metabolism; phosphatidylserine biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular FunctionL-serine-phosphatidylethanolamine phosphatidyltransferase activity
Biological Processphosphatidylserine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylserine synthase
  • EC number
  • Alternative names
    • Serine-exchange enzyme

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A8KAH1

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane36-57Helical
Transmembrane69-88Helical
Transmembrane100-121Helical
Transmembrane188-207Helical
Transmembrane219-240Helical
Transmembrane283-300Helical
Transmembrane320-342Helical
Transmembrane354-372Helical
Transmembrane384-406Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias430-455Basic and acidic residues
Region430-473Disordered
Compositional bias456-473Basic residues

Sequence similarities

Belongs to the phosphatidyl serine synthase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    473
  • Mass (Da)
    55,468
  • Last updated
    2007-12-04 v1
  • Checksum
    5A825CA65BEE86A4
MASCVGSRTLSKDDVNYKMHFRMINEQQVEDITIDFFYRPHTITLLSFTIVSLMYFAFTRDDSVPEDNIWRGILSVIFFFLIISVLAFPNGPFTRPHPALWRMVFGLSVLCFLFLVFLLFLNFEQVKSLMYWLDPNLRYATREADVMEYAVNCHVITWERIISHFDIFAFGHFWGWAMKALLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMVVCRFLEMRTYHWASFKDIHTTTGKIKRAVLQFTPASWTYVRWFDPKSSFQRVAGVYLFMIIWQLTELNTFFLKHIFVFQASHPLSWGRILFIGGITAPTVRQYYAYLTDTQCKRVGTQCWVFGVIGFLEAIVCIKFGQDLFSKTQILYVVLWLLCVAFTTFLCLYGMIWYAEHYGHREKTYSECEDGTYSPEISWHHRKGTKGSEDSPPKHAGNNESHSSRRRNRHSKSKVTNGVGKK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias430-455Basic and acidic residues
Compositional bias456-473Basic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK293036
EMBL· GenBank· DDBJ
BAF85725.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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