Data suggest that TYMS exhibits a ligand-binding site in dimer interface suggesting that cavity in dimer interface serves as an allosteric site to regulate conformational switching between active and inactive states of the enzyme.
crystal structures of human TS (hTS) complexes with FdUMP and dUMP were obtained indicating that this form should facilitate high-throughput analysis of hTS complexes with drug candidates
Molecular features of thymidylate synthase that control its degradation are examined; the carboxyl-terminal conformational shift is not required for ligand-mediated stabilization; the amino-terminus governs TS stability and its response to ligands.
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