A8K8W7 · A8K8W7_HUMAN
- ProteinHormone-sensitive lipase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1076 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2OThis reaction proceeds in the backward direction.
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+This reaction proceeds in the forward direction.
- 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+This reaction proceeds in the forward direction.
- 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+This reaction proceeds in the forward direction.
- 2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+This reaction proceeds in the forward direction.
- all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H+ + hexadecanoateThis reaction proceeds in the forward direction.
- cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H+This reaction proceeds in the forward direction.
Pathway
Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 725 | |||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | caveola | |
Cellular Component | cytosol | |
Cellular Component | lipid droplet | |
Molecular Function | acylglycerol lipase activity | |
Molecular Function | hormone-sensitive lipase activity | |
Molecular Function | sterol esterase activity | |
Molecular Function | triglyceride lipase activity | |
Biological Process | cholesterol metabolic process | |
Biological Process | triglyceride catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameHormone-sensitive lipase
- EC number
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA8K8W7
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Disease & Variants
Organism-specific databases
PTM/Processing
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Polar residues | ||||
Sequence: MEPGSKSVSRSDWQPE | ||||||
Region | 1-198 | Disordered | ||||
Sequence: MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQQETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYVQRVLLTQQEAASQQGPGLGKESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQETPEQSDKQTTPVQGAKSKQ | ||||||
Compositional bias | 36-66 | Polar residues | ||||
Sequence: QPESKTLQGSNTQQKPASNQRPLTQQETPAQ | ||||||
Compositional bias | 95-132 | Polar residues | ||||
Sequence: PQQSPYVQRVLLTQQEAASQQGPGLGKESITQQEPALR | ||||||
Compositional bias | 170-198 | Polar residues | ||||
Sequence: SAPTESTSQETPEQSDKQTTPVQGAKSKQ | ||||||
Compositional bias | 229-249 | Polar residues | ||||
Sequence: VTDSESESDVGSSSDTDSPAT | ||||||
Region | 229-250 | Disordered | ||||
Sequence: VTDSESESDVGSSSDTDSPATM | ||||||
Domain | 308-615 | Hormone-sensitive lipase N-terminal | ||||
Sequence: TQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWKAFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQD | ||||||
Domain | 647-795 | Alpha/beta hydrolase fold-3 | ||||
Sequence: IVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVLSKCVSAYAGAKTEDH | ||||||
Region | 838-930 | Disordered | ||||
Sequence: KSQKMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAKNELSP | ||||||
Compositional bias | 866-909 | Polar residues | ||||
Sequence: LGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDV | ||||||
Domain | 962-1027 | Alpha/beta hydrolase fold-3 | ||||
Sequence: SPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVEDLPHGFL | ||||||
Region | 1055-1076 | Disordered | ||||
Sequence: AGAGPSGETGAAGVDGGCGGRH |
Sequence similarities
Belongs to the 'GDXG' lipolytic enzyme family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,076
- Mass (Da)116,584
- Last updated2007-12-04 v1
- Checksum01AF00E31ABF8CCA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Polar residues | ||||
Sequence: MEPGSKSVSRSDWQPE | ||||||
Compositional bias | 36-66 | Polar residues | ||||
Sequence: QPESKTLQGSNTQQKPASNQRPLTQQETPAQ | ||||||
Compositional bias | 95-132 | Polar residues | ||||
Sequence: PQQSPYVQRVLLTQQEAASQQGPGLGKESITQQEPALR | ||||||
Compositional bias | 170-198 | Polar residues | ||||
Sequence: SAPTESTSQETPEQSDKQTTPVQGAKSKQ | ||||||
Compositional bias | 229-249 | Polar residues | ||||
Sequence: VTDSESESDVGSSSDTDSPAT | ||||||
Compositional bias | 866-909 | Polar residues | ||||
Sequence: LGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDV |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK292482 EMBL· GenBank· DDBJ | BAF85171.1 EMBL· GenBank· DDBJ | mRNA |