A8K2V7 · A8K2V7_HUMAN
- ProteinNAD(P)H oxidase (H2O2-forming)
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1551 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Catalytic activity
- H+ + NADH + O2 = H2O2 + NAD+
Pathway
Hormone biosynthesis; thyroid hormone biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | NADPH oxidase complex | |
Molecular Function | calcium ion binding | |
Molecular Function | heme binding | |
Molecular Function | NAD(P)H oxidase H2O2-forming activity | |
Molecular Function | peroxidase activity | |
Molecular Function | superoxide-generating NAD(P)H oxidase activity | |
Biological Process | defense response | |
Biological Process | hormone biosynthetic process | |
Biological Process | response to oxidative stress | |
Biological Process | superoxide anion generation | |
Biological Process | thyroid hormone generation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD(P)H oxidase (H2O2-forming)
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA8K2V7
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 593-617 | Helical | ||||
Sequence: FGFGVTIGTLCCFPLVSLLSAWIVA | ||||||
Transmembrane | 1045-1068 | Helical | ||||
Sequence: IGCVAVFYAIAGGLFLERAYYYAF | ||||||
Transmembrane | 1088-1109 | Helical | ||||
Sequence: GTAASISFMFSYILLTMCRNLI | ||||||
Transmembrane | 1152-1171 | Helical | ||||
Sequence: VYLFSISPLSVLSCLFPGLF | ||||||
Transmembrane | 1183-1209 | Helical | ||||
Sequence: YWWFFQTVPGLTGVVLLLILAIMYVFA | ||||||
Transmembrane | 1221-1243 | Helical | ||||
Sequence: FWLTHHLYILLYVLLIIHGSFAL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MGFCLALAWTLLVGAWTPLGA | ||||||
Chain | PRO_5002724620 | 22-1551 | NAD(P)H oxidase (H2O2-forming) | |||
Sequence: QNPISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSWLELLPGGLLESHRDPGPLFSTIVLEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLVAVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTLCCFPLVSLLSAWIVARLRMRNFKRLQGQDRQSIVSEKLVGGMEALEWQGHKEPCRPVLVYLQPGQIRVVDGRLTVLRTIQLQPPQKVNFVLSSNRGRRTLLLKIPKEYDLVLLFNLEEERQALVENLRGALKESGLSIQEWELREQELMRAAVTREQRRHLLETFFRHLFSQVLDINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHNSELRFTQLCVKGVEVPEVIKDLCRRASYISQDMICPSPRVSARCSRSDIETELTPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSRLHQTVQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVLTVLHSVGHVVNVYLFSISPLSVLSCLFPGLFHDDGSEFPQKYYWWFFQTVPGLTGVVLLLILAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF |
Keywords
- PTM
Proteomic databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 150-172 | Disordered | ||||
Sequence: RWDPETGRSPSNPRDPANQVTGW | ||||||
Compositional bias | 153-167 | Polar residues | ||||
Sequence: PETGRSPSNPRDPAN | ||||||
Domain | 815-850 | EF-hand | ||||
Sequence: PQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKG | ||||||
Domain | 851-886 | EF-hand | ||||
Sequence: SPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEI | ||||||
Domain | 1270-1376 | FAD-binding FR-type | ||||
Sequence: RKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPFGEGHQE |
Sequence similarities
In the N-terminal section; belongs to the peroxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,551
- Mass (Da)177,322
- Last updated2007-12-04 v1
- Checksum09BDB04C159394B9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 153-167 | Polar residues | ||||
Sequence: PETGRSPSNPRDPAN |