A8K168 · A8K168_HUMAN

Function

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Divalent metal cations. Prefers magnesium or manganese.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site, binding site.

157250100150200250300350400450500550
TypeIDPosition(s)Description
Active site102Proton donor
Binding site155substrate
Active site173Proton acceptor
Binding site245a divalent metal cation (UniProtKB | ChEBI)
Binding site246a divalent metal cation (UniProtKB | ChEBI)
Binding site269a divalent metal cation (UniProtKB | ChEBI)
Binding site408substrate
Binding site453substrate

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functionmalate dehydrogenase (decarboxylating) (NADP+) activity
Molecular Functionmetal ion binding
Molecular FunctionNAD binding
Biological Processmalate metabolic process
Biological Processpyruvate metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Malic enzyme

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A8K168

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain79-260Malic enzyme N-terminal
Domain270-522Malic enzyme NAD-binding

Sequence similarities

Belongs to the malic enzymes family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    572
  • Mass (Da)
    64,136
  • Last updated
    2007-12-04 v1
  • Checksum
    FD47EF316976130F
MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPVIFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFVRSQMYSTDYDQILPDCYSWPEEVQKIQTKVDQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK289783
EMBL· GenBank· DDBJ
BAF82472.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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