A8K168 · A8K168_HUMAN
- ProteinMalic enzyme
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids572 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Divalent metal cations. Prefers magnesium or manganese.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 102 | Proton donor | ||||
Sequence: Y | ||||||
Binding site | 155 | substrate | ||||
Sequence: R | ||||||
Active site | 173 | Proton acceptor | ||||
Sequence: K | ||||||
Binding site | 245 | a divalent metal cation (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 246 | a divalent metal cation (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 269 | a divalent metal cation (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 408 | substrate | ||||
Sequence: N | ||||||
Binding site | 453 | substrate | ||||
Sequence: N |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | malate dehydrogenase (decarboxylating) (NADP+) activity | |
Molecular Function | metal ion binding | |
Molecular Function | NAD binding | |
Biological Process | malate metabolic process | |
Biological Process | pyruvate metabolic process |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMalic enzyme
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA8K168
Subcellular Location
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 79-260 | Malic enzyme N-terminal | ||||
Sequence: QDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYR | ||||||
Domain | 270-522 | Malic enzyme NAD-binding | ||||
Sequence: IQGTASVAVAGLLAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPVIFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAY |
Sequence similarities
Belongs to the malic enzymes family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length572
- Mass (Da)64,136
- Last updated2007-12-04 v1
- ChecksumFD47EF316976130F