A8K0L6 · A8K0L6_HUMAN
- ProteinPhosphatidylinositol-3-phosphate phosphatase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1198 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 326-329 | substrate | ||||
Sequence: NRAK | ||||||
Binding site | 351-352 | substrate | ||||
Sequence: NI | ||||||
Active site | 413 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 413-419 | substrate | ||||
Sequence: CSDGWDR |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Molecular Function | metal ion binding | |
Molecular Function | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | |
Molecular Function | phosphatidylinositol-3-phosphate phosphatase activity | |
Molecular Function | protein phosphatase binding | |
Molecular Function | protein tyrosine phosphatase activity | |
Biological Process | phosphatidylinositol dephosphorylation | |
Biological Process | regulation of autophagy |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylinositol-3-phosphate phosphatase
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA8K0L6
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 155-576 | Myotubularin phosphatase | ||||
Sequence: EHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVY | ||||||
Compositional bias | 265-283 | Polar residues | ||||
Sequence: SRSSGSKLSTRNTSRDFPN | ||||||
Region | 265-285 | Disordered | ||||
Sequence: SRSSGSKLSTRNTSRDFPNGG | ||||||
Region | 590-612 | Disordered | ||||
Sequence: CAPYPAPGTSPDDPPLSRLPKTR | ||||||
Region | 650-669 | Disordered | ||||
Sequence: LSSLAGPGEDPLSADSLGKP | ||||||
Region | 716-735 | Disordered | ||||
Sequence: EGKEDPLLEKESRRKTPEAS | ||||||
Region | 855-891 | Disordered | ||||
Sequence: KSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVE | ||||||
Compositional bias | 872-891 | Polar residues | ||||
Sequence: GKDRLPQTMEPSPSETSLVE | ||||||
Region | 933-974 | Disordered | ||||
Sequence: ETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQL | ||||||
Compositional bias | 934-954 | Polar residues | ||||
Sequence: TENRASEQPPGLSTLQMYPTP | ||||||
Region | 993-1019 | Disordered | ||||
Sequence: WLHSHSGRPSATSSPDQPSRSHLDDDG | ||||||
Coiled coil | 1035-1062 | |||||
Sequence: ESGHQQEVETLKKQVQELKSRLESQYLT | ||||||
Domain | 1119-1179 | FYVE-type | ||||
Sequence: DHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLH |
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,198
- Mass (Da)133,618
- Last updated2007-12-04 v1
- ChecksumEE214B165074D5FB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 265-283 | Polar residues | ||||
Sequence: SRSSGSKLSTRNTSRDFPN | ||||||
Compositional bias | 872-891 | Polar residues | ||||
Sequence: GKDRLPQTMEPSPSETSLVE | ||||||
Compositional bias | 934-954 | Polar residues | ||||
Sequence: TENRASEQPPGLSTLQMYPTP |