A8JYA3 · A8JYA3_OREMO
- ProteinGlycogen [starch] synthase
- GeneGS
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids711 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Catalytic activity
- [(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H+ + UDPThis reaction proceeds in the forward direction.
[(1→4)-α-D-glucosyl](n) RHEA-COMP:9584 + CHEBI:58885 = [(1→4)-α-D-glucosyl](n+1) RHEA-COMP:9587 + CHEBI:15378 + CHEBI:58223
Pathway
Glycan biosynthesis; glycogen biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | glycogen (starch) synthase activity | |
Biological Process | glycogen biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGlycogen [starch] synthase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > African cichlids > Pseudocrenilabrinae > Oreochromini > Oreochromis
Accessions
- Primary accessionA8JYA3
Interaction
Subunit
Part of the GYS1-GYG1 complex, a heterooctamer composed of a tetramer of GYS1 and 2 dimers of GYG1, where each GYS1 protomer binds to one GYG1 subunit (via GYG1 C-terminus); the GYS1 tetramer may dissociate from GYG1 dimers to continue glycogen polymerization on its own.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 632-685 | Disordered | ||||
Sequence: AGFRYPRPASVPPSPALSRHSSPHHSEAEDNEDDERYDEDLEAEKDKVNIRQPY | ||||||
Region | 692-711 | Disordered | ||||
Sequence: KSIAIIGANGNGDKVTSEKN |
Sequence similarities
Belongs to the glycosyltransferase 3 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length711
- Mass (Da)80,943
- Last updated2007-12-04 v1
- ChecksumCBA0FED2065546AD