A8JR46 · A8JR46_DROME
- Proteinnon-specific serine/threonine protein kinase
- GeneIre1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1074 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | IRE1-TRAF2-ASK1 complex | |
Molecular Function | ATP binding | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | RNA endonuclease activity | |
Molecular Function | unfolded protein binding | |
Biological Process | cellular response to starvation | |
Biological Process | compound eye photoreceptor cell differentiation | |
Biological Process | endoplasmic reticulum unfolded protein response | |
Biological Process | Golgi organization | |
Biological Process | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | |
Biological Process | IRE1-mediated unfolded protein response | |
Biological Process | lipid homeostasis | |
Biological Process | mRNA catabolic process | |
Biological Process | mRNA processing | |
Biological Process | negative regulation of organ growth | |
Biological Process | regulation of RNA splicing | |
Biological Process | response to endoplasmic reticulum stress | |
Biological Process | rhabdomere morphogenesis | |
Biological Process | triglyceride mobilization |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namenon-specific serine/threonine protein kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionA8JR46
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MRFCVVVCCVLFLLASGLIASATA | ||||||
Chain | PRO_5002724505 | 25-1074 | non-specific serine/threonine protein kinase | |||
Sequence: KSQQGDSAEVVSSGEDEKTDCTDLARDEEALMVFSTLGGGLTAIDPVTSEIRWTIADDPPIVAEHQENVQVPHFLPDPRDGSIYQLGQMGSLKKLPYTIPQLVANAPCRSSDGILYSGKKSDTWYMVDPKTGRREKVMGFGDATVDGKEGEQIGWATSRAIYLGRTQYTVMMYDSLAKNKDAKPWNITFYDYNAVSAPPELAKEYEYIHLTTTTNGQIVTLDRKHGKFLWQRDLSSPVVAAFLLGPDGLLSVPFTTVSDEAYQAILEESKTGNVNTVKLFQSLYVGEHQKGLYALPSLVDKNTPRISTAPPIKLLDGPTGDQNSNQETDPRTIYINDVLQEHAGIMLGHYNMPNEGNGNLQLSPTTASSKVVQSLATIHNYNDGYGLLANNEKNAADIGVQTDPELVEIGIDQRTNGNTINRTKTIILQNSNKVQAFINEWFMEHPSGKVHQILIVIVLGMIALFWYTCSTMRELQKQSENGSKTFAIAQNGSNGSTGSNGSNANAEDLVDLGNGQVRVGKISFSTNEVLGKGCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAATLQDYTEGDRSLELQNHIDVWQVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMRSQRTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEDSRIILAEQLISDMIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDVSDRVEKLQFHAEPLKSLEKNGRIVVLDDWNVHLDPMITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFTNYWVDRFPQLISHAYHAFSICSNEPIFKPYYSAGYLFTRPWYFDADDALFPMLMLDPKPLPKIGSPKKTPSPASSQAQQLKQRKGLYNFRKPNDELPIPGVGLQRNLELDGQSLEPDGKRDVFANFKFRRYSKPGNNRNYNGGHKEAQDKEKYVIWTLPPSTQD |
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 333-354 | Disordered | ||||
Sequence: APPIKLLDGPTGDQNSNQETDP | ||||||
Domain | 548-812 | Protein kinase | ||||
Sequence: FSTNEVLGKGCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAATLQDYTEGDRSLELQNHIDVWQVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMRSQRTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEDSRIILAEQLISDMIHKDPQSRPPARCIGNHPLF | ||||||
Domain | 815-943 | KEN | ||||
Sequence: EPKMLSFLQDVSDRVEKLQFHAEPLKSLEKNGRIVVLDDWNVHLDPMITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFTNYWVDRFPQLISHAYHAFSICSNEPIFKPYYSA | ||||||
Region | 971-991 | Disordered | ||||
Sequence: PKIGSPKKTPSPASSQAQQLK |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,074
- Mass (Da)120,171
- Last updated2007-12-04 v1
- Checksum641150211C872FE9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014297 EMBL· GenBank· DDBJ | ABW08704.1 EMBL· GenBank· DDBJ | Genomic DNA |