A8JQ65 · DGKH_DROME
- ProteinDiacylglycerol kinase eta
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1895 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).
Catalytic activity
- a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP-dependent diacylglycerol kinase activity | |
Molecular Function | metal ion binding | |
Biological Process | diacylglycerol metabolic process | |
Biological Process | intracellular signal transduction | |
Biological Process | lipid phosphorylation | |
Biological Process | phosphatidic acid biosynthetic process | |
Biological Process | phospholipase C-activating G protein-coupled receptor signaling pathway |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDiacylglycerol kinase eta
- EC number
- Short namesDAG kinase eta
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionA8JQ65
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000375987 | 1-1895 | Diacylglycerol kinase eta | ||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, zinc finger.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-37 | Disordered | |||
Compositional bias | 15-36 | Polar residues | |||
Domain | 82-175 | PH | |||
Zinc finger | 195-245 | Phorbol-ester/DAG-type 1 | |||
Zinc finger | 267-318 | Phorbol-ester/DAG-type 2 | |||
Domain | 349-485 | DAGKc | |||
Region | 781-801 | Disordered | |||
Region | 1012-1053 | Disordered | |||
Compositional bias | 1113-1127 | Basic and acidic residues | |||
Region | 1113-1137 | Disordered | |||
Compositional bias | 1172-1186 | Polar residues | |||
Region | 1172-1191 | Disordered | |||
Domain | 1832-1895 | SAM | |||
Sequence similarities
Belongs to the eukaryotic diacylglycerol kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,895
- Mass (Da)211,659
- Last updated2007-12-04 v1
- MD5 Checksum21BF3AEF144982A244901A08A821C739
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0B4K6B6 | A0A0B4K6B6_DROME | CG31187 | 1936 | ||
A0A0B4K634 | A0A0B4K634_DROME | CG31187 | 1918 | ||
A0A0B4K6W3 | A0A0B4K6W3_DROME | CG2667 | 1871 | ||
A0A0B4LHW4 | A0A0B4LHW4_DROME | CG31187 | 1894 | ||
E2QD61 | E2QD61_DROME | CG2667 | 1733 |
Sequence caution
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 15-36 | Polar residues | |||
Compositional bias | 1113-1127 | Basic and acidic residues | |||
Compositional bias | 1172-1186 | Polar residues | |||
Sequence conflict | 1192-1215 | in Ref. 3; AAO39647 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014297 EMBL· GenBank· DDBJ | ABW08617.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT003643 EMBL· GenBank· DDBJ | AAO39647.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. |