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A8JQ65 · DGKH_DROME

Function

function

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP-dependent diacylglycerol kinase activity
Molecular Functionmetal ion binding
Biological Processdiacylglycerol metabolic process
Biological Processintracellular signal transduction
Biological Processlipid phosphorylation
Biological Processphosphatidic acid biosynthetic process
Biological Processphospholipase C-activating G protein-coupled receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diacylglycerol kinase eta
  • EC number
  • Short names
    DAG kinase eta

Gene names

    • ORF names
      CG34384

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    A8JQ65
  • Secondary accessions
    • Q86NT9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003759871-1895Diacylglycerol kinase eta

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain, zinc finger.

Type
IDPosition(s)Description
Region1-37Disordered
Compositional bias15-36Polar residues
Domain82-175PH
Zinc finger195-245Phorbol-ester/DAG-type 1
Zinc finger267-318Phorbol-ester/DAG-type 2
Domain349-485DAGKc
Region781-801Disordered
Region1012-1053Disordered
Compositional bias1113-1127Basic and acidic residues
Region1113-1137Disordered
Compositional bias1172-1186Polar residues
Region1172-1191Disordered
Domain1832-1895SAM

Sequence similarities

Belongs to the eukaryotic diacylglycerol kinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,895
  • Mass (Da)
    211,659
  • Last updated
    2007-12-04 v1
  • MD5 Checksum
    21BF3AEF144982A244901A08A821C739
MAHLKLDTLHVQRSPRGSRRSSPSSGRSSACSSGSISPVPIIPIISISHDGDESESESEIETEPARLFQRRMSTKCTNNLAAIIKEGFLLKHTWSFQRWRRRYFRLKRNMLFYAKDEKCDVFDDIDLSDLCYFECGIKNVNHSFQIITPTRSLVLCAESRREMEDWLGSLKTATAPQRPRGDSFLIEQHDILSNHHHWYATSHARPTYCNVCRDALSGVTSHGLSCEVCKCKVHKRCAAKSIANCKWTTLASVGKDIIEQADGIIMPHQWMEGNLPVSSMCAVCKKTCGSVLRLQDWRCLWCRATVHVACRPQMAVACPIGPAKLSVVPPTSVHSISTDDAWDVASPKGNFSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLISTGPSLGLRLFRHFEMFRILVCSGDGSVGWVLSEIDRFNMHKQCQVAVMPLGTGNDLARVLGWGSSCDDDTHLPQILERYESASTKMLDRWSIMVFEKAIPVPKTPKMSISTEQEAMLTGMVTSANHHLRFIVETNDTQTLIRSTRNLCDTVDDLVCRISEHHKDDEQLAVKCDILRQKLNMLLDALQEEEIGAHSGDDLIATIRSLIARSIPVTPGSNAYLLNPNISIEKTEKDQINTKERRNSRSLRSSEKEALQCRANSVKRAIYNVVEHSEPGRPKRYQRKLSITPFEALKLPTASGESTPCTSPLPIIPPINIISPTMETSRLTCISPLPDTRRDSVDENFFNSINLPAPRQFADSRRSSGVEVIQEIEEGANGETVYRKSRMSLTGGANIDDAGNRLSPCSDAGENTPTERKVDFLRVPIHTGEPIVDPLCDYRPHEVFERTYYMTREMDKGKEKDKEKDKPVEIDKEKDTCVEKEGSMPAEKLVHTCNLQVPGVVVTPNPQNVYSSASITIIDTDAQTTTEQSSSDDLGGEASDVLSAISNEECSVASEIFDKQDAGQTVGDIIQNMDASNFTHIDSPETSDETEAMPGESIMDDISSVLGHDITYALQDNTLTDDTTTLCSEHAGPPKPPRKKSLSALSRTQAHPRRRNSSPPRMARLARMDSDDNPQQFGFENIVFEIDNRCDDQKMREPPRYCSLAQFVEGNDIARQSFKQLMLEQHRGGDNDSDYPEHEQTPTNKGANLLATTSEDELSTQTAIKIEIQDIDATVRNLNSSMKPNTILTTSTSPTKKSGHGQDVKRITFDESCKKESFDDVNPNYPQISVVVRPPTPLRGDCIKPTVSLLPVSSGGAMTVSMTCSGMLGVRAMNASEIRRHSSHAPGLAVREFDKDKDRRHSGFNPNQLTLDPEHARFLSSSPAASRRISCGSLFKPNEALPNLQTLKGSKSSLFMGSTLFGFDHLASAEKDKEEKSGKDKEKTPTDETNRKLPIINPLVRLPNWPNLANGGGFISKCLLANADTLCAAVSPLMDPDETLLAGYHEKCVMNNYFGIGIDAKISLDFHNKREEHPEKCRSRARNYMWYGVLGSKQLLQKTCKNLEQRVQLECDGQRIPLPELQGIVILNIPSFMGGTNFWGSSKKDDIFLPPSFDDRVLEVVAVFGSVQMAASRLINLQHHRIAQCQSVQINILGDEEIPIQVDGEAWLQPPGMIRILHKNRVQMLCRNRSLELSLKSWQEKQRQHSISIQRDASSTASEHANSTDEVISERECYVLLNFIEAVSSLVKWVKFLIISHPALQHDLYEVACRASEALESIHPQGKLLEGPSLRTKLVEVIDSSRQLYDDACTLLRDRGHSLILREDLETKLSAALANMEMELKKCSVQKCIDGKLRAYFNVLAPNEESDGRRKSRPFWVRLRSGSTAGQQAFKPPLTNTREAANNWSVNEVVTWLETMQLSEYVDSFLKNDIRGKELLTLGRRDLKDLGVVKVGHVKRILQAIKDLSEN

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0B4K6B6A0A0B4K6B6_DROMECG311871936
A0A0B4K634A0A0B4K634_DROMECG311871918
A0A0B4K6W3A0A0B4K6W3_DROMECG26671871
A0A0B4LHW4A0A0B4LHW4_DROMECG311871894
E2QD61E2QD61_DROMECG26671733

Sequence caution

The sequence AAO39647.1 differs from that shown. Reason: Miscellaneous discrepancy Frameshift and deletion of residues 1685-1699.

Features

Showing features for compositional bias, sequence conflict.

Type
IDPosition(s)Description
Compositional bias15-36Polar residues
Compositional bias1113-1127Basic and acidic residues
Compositional bias1172-1186Polar residues
Sequence conflict1192-1215in Ref. 3; AAO39647

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014297
EMBL· GenBank· DDBJ
ABW08617.1
EMBL· GenBank· DDBJ
Genomic DNA
BT003643
EMBL· GenBank· DDBJ
AAO39647.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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