A8JNN2 · A8JNN2_DROME
- ProteinADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- GeneSarm
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1562 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- H2O + NAD+ = ADP-D-ribose + H+ + nicotinamideThis reaction proceeds in the forward direction.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | NAD+ nucleosidase activity | |
Molecular Function | NAD+ nucleotidase, cyclic ADP-ribose generating | |
Molecular Function | signaling adaptor activity | |
Biological Process | innate immune response | |
Biological Process | NAD catabolic process | |
Biological Process | negative regulation of MyD88-independent toll-like receptor signaling pathway | |
Biological Process | response to axon injury | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionA8JNN2
Proteomes
Organism-specific databases
Expression
Gene expression databases
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-26 | Disordered | ||||
Sequence: MVVTSTRSPLLAQTQPANASTSGTHT | ||||||
Region | 43-83 | Disordered | ||||
Sequence: MTDFSDSSPSGVLSPPTSLIENFHKKNSSPQPLGSSSAIST | ||||||
Region | 95-178 | Disordered | ||||
Sequence: GGGVGGAGHHSIENGRQINTSSSSCSSLKETSHQSTSTSQQVVNSSSSTTTRVEKKSQRLHHHITSSSSSSSTTQALSTSSEMK | ||||||
Compositional bias | 107-147 | Polar residues | ||||
Sequence: ENGRQINTSSSSCSSLKETSHQSTSTSQQVVNSSSSTTTRV | ||||||
Compositional bias | 157-176 | Polar residues | ||||
Sequence: HITSSSSSSSTTQALSTSSE | ||||||
Region | 203-233 | Disordered | ||||
Sequence: RITGGPGSISTTSASAITAPSTMSQTTTSRL | ||||||
Compositional bias | 207-233 | Polar residues | ||||
Sequence: GPGSISTTSASAITAPSTMSQTTTSRL | ||||||
Domain | 866-930 | SAM | ||||
Sequence: WSVEDVQEWVKQIGFNDYIDKFNESQVDGDLLLKLNQDNLRADIGIGNGILLKRFERELQNLKRM | ||||||
Domain | 1013-1157 | TIR | ||||
Sequence: KTLDVFVSYRRSNGSQLASLLKVHLQLRGFSVFIDVERLEAGKFDNGLLNSIRQAKNFVLVLTPDALHRCINDEDCKDWVHREIVAALNSNCNIIPIIDQQFDWPEVERLPEDMRSVAHFNGVNWIHDYQDACIDKLERFLRGEK | ||||||
Compositional bias | 1173-1188 | Polar residues | ||||
Sequence: VSYQRMHSNDSDYQSG | ||||||
Region | 1173-1202 | Disordered | ||||
Sequence: VSYQRMHSNDSDYQSGGAGAGSGAGTGGGG | ||||||
Region | 1222-1261 | Disordered | ||||
Sequence: GQANHQANRYRQSPSPARQRGSTSQLSGYSRAPSKRSQIL | ||||||
Region | 1297-1324 | Disordered | ||||
Sequence: SAAGLGHGSGSGMGSGYRSHSVDGLLDQ | ||||||
Region | 1368-1392 | Disordered | ||||
Sequence: NDSVTRRDKHTLSPPGNVQQHRKSR | ||||||
Compositional bias | 1425-1443 | Polar residues | ||||
Sequence: IPMTPQPQRRDTSSSSKSP | ||||||
Region | 1425-1516 | Disordered | ||||
Sequence: IPMTPQPQRRDTSSSSKSPTPERPPQPAMERVRERQSPEGVSATESEREDQPEECLRHGNQQRASASVHRGASLTSNKTSNSSLGSNFSAGG | ||||||
Compositional bias | 1451-1481 | Basic and acidic residues | ||||
Sequence: PAMERVRERQSPEGVSATESEREDQPEECLR | ||||||
Compositional bias | 1482-1516 | Polar residues | ||||
Sequence: HGNQQRASASVHRGASLTSNKTSNSSLGSNFSAGG |
Sequence similarities
Belongs to the SARM1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,562
- Mass (Da)169,060
- Last updated2007-12-04 v1
- Checksum5A4B60ED4DC53CE7
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 107-147 | Polar residues | ||||
Sequence: ENGRQINTSSSSCSSLKETSHQSTSTSQQVVNSSSSTTTRV | ||||||
Compositional bias | 157-176 | Polar residues | ||||
Sequence: HITSSSSSSSTTQALSTSSE | ||||||
Compositional bias | 207-233 | Polar residues | ||||
Sequence: GPGSISTTSASAITAPSTMSQTTTSRL | ||||||
Compositional bias | 1173-1188 | Polar residues | ||||
Sequence: VSYQRMHSNDSDYQSG | ||||||
Compositional bias | 1425-1443 | Polar residues | ||||
Sequence: IPMTPQPQRRDTSSSSKSP | ||||||
Compositional bias | 1451-1481 | Basic and acidic residues | ||||
Sequence: PAMERVRERQSPEGVSATESEREDQPEECLR | ||||||
Compositional bias | 1482-1516 | Polar residues | ||||
Sequence: HGNQQRASASVHRGASLTSNKTSNSSLGSNFSAGG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014296 EMBL· GenBank· DDBJ | ABW08491.1 EMBL· GenBank· DDBJ | Genomic DNA |