A8JNN1 · A8JNN1_DROME

Function

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionNAD+ nucleosidase activity
Molecular FunctionNAD+ nucleotidase, cyclic ADP-ribose generating
Molecular Functionsignaling adaptor activity
Biological Processinnate immune response
Biological Processnegative regulation of MyD88-independent toll-like receptor signaling pathway
Biological Processresponse to axon injury
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
  • EC number

Gene names

    • Name
      Sarm
    • Synonyms
      anon-WO0118547.272
      , CG13680
      , CG13681
      , CG34373
      , CG7905
      , CG7915
      , Dmel\CG43119
      , dSARM
      , dSarm
      , dsarm
      , dSARM1
      , ECT4
      , Ect4
      , ect4
      , Ect4/SARM
      , SARM
      , SARM1
    • ORF names
      CG43119
      , Dmel_CG43119

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    A8JNN1

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region21-58Disordered
Compositional bias25-39Basic and acidic residues
Region119-158Disordered
Region170-253Disordered
Compositional bias182-222Polar residues
Compositional bias232-251Polar residues
Region278-308Disordered
Compositional bias282-308Polar residues
Domain941-1005SAM
Domain1088-1232TIR
Compositional bias1248-1263Polar residues
Region1248-1277Disordered
Region1297-1336Disordered
Region1372-1399Disordered
Region1443-1467Disordered
Compositional bias1500-1518Polar residues
Region1500-1591Disordered
Compositional bias1526-1556Basic and acidic residues
Compositional bias1557-1591Polar residues

Sequence similarities

Belongs to the SARM1 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,637
  • Mass (Da)
    177,769
  • Last updated
    2007-12-04 v1
  • Checksum
    0B224953E27C75B5
MGNRLSGLWCKKTTLSITQQEEQQYNREIRNEKSPPRSGRKSNRIRTKSSGSGDGRGTFRLASIRRLSLRDNPKKTIKTPLDNPSIATVEQTFRELTKRADLDSSMKVNAQLMPTVKMTDFSDSSPSGVLSPPTSLIENFHKKNSSPQPLGSSSAISTLTPTTLNGSVVGGGVGGAGHHSIENGRQINTSSSSCSSLKETSHQSTSTSQQVVNSSSSTTTRVEKKSQRLHHHITSSSSSSSTTQALSTSSEMKAAEIKRDLTNIQKSMSEINDLAKERITGGPGSISTTSASAITAPSTMSQTTTSRLAPKLTSAHPSIDDLRGLSRQDKITQLQKKIRASFENLVDHDDSNVIVTLPDDDDCPHNHFGSGLNLTHPTAAQLSASGLSGSSKTIDTIKFQEKSMKTESKTKVVTDGFSSEQATSNSAEMKRLQAGDIDYQESKGASAMRNRLEVDGVKTEENAAVIKEALSLRTGDITQQASNNVAASSITVQSENFSADKKAISQSQQSQTMTSNGIISQEKHVSSASQANYSMSHKGVSSTGSSMITSSSQMSAMNGQMLKLADLKLDDLKSLTAGSGQQEIEQTINKYSNMLTSIVSSLQEDERGGSAITVHDVGGKKSQYLEKINEVIRRAWAVPTHGHELGYSLCNSLRQSGGLDLLMKNCVKPDLQFSSAQLLEQCLTTENRKHVVDNGLDKVVNVACVCTKNSNMEHSRVGTGILEHLFKHSEGTCSDVIRLGGLDAVLFECRTSDLETLRHCASALANLSLYGGAENQEEMILRKVPMWLFPLAFHNDDNIKYYACLAIAVLVANKEIEAEVLKSGCLDLVEPFVTSHDPSAFARSNLAHAHGQSKHWLKRLVPVLSSNREEARNLAAFHFCMEAGIKREQGNTDIFREINAIEALKNVASCPNAIASKFAAQALRLIGETVPHKLSQQVPLWSVEDVQEWVKQIGFNDYIDKFNESQVDGDLLLKLNQDNLRADIGIGNGILLKRFERELQNLKRMADYSSKDTAKMHQFLSEIGTDYCTYTYAMLNAGIDKCALPHVNEDMLMTECGIHNSIHRLRILNAVKNLENSLPSSSEENMAKTLDVFVSYRRSNGSQLASLLKVHLQLRGFSVFIDVERLEAGKFDNGLLNSIRQAKNFVLVLTPDALHRCINDEDCKDWVHREIVAALNSNCNIIPIIDQQFDWPEVERLPEDMRSVAHFNGVNWIHDYQDACIDKLERFLRGEKNIDRIAAMVPGTPGSVSYQRMHSNDSDYQSGGAGAGSGAGTGGGGGGGVTGSVVDGLMVAANGSGQANHQANRYRQSPSPARQRGSTSQLSGYSRAPSKRSQILTPYRTQQAALLHKTGAGSASMQNMMPLAYLPPRRSSAAGLGHGSGSGMGSGYRSHSVDGLLDQAGSTPEQRIAAAAAKVTAGSTALTNASSTSTLQPEEEVTDAALNDSVTRRDKHTLSPPGNVQQHRKSRSLDHILSKQTLAELLPPSSELADGTQSMQNLAIPMTPQPQRRDTSSSSKSPTPERPPQPAMERVRERQSPEGVSATESEREDQPEECLRHGNQQRASASVHRGASLTSNKTSNSSLGSNFSAGGNNKTIFNRTMKKVRSLIKNNEMEDEELSGIILSKATSPNAGRMIFW

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q6IDD9SARM1_DROMESarm1360
A8JNN2A8JNN2_DROMESarm1562
A8JNN3A8JNN3_DROMESarm1386
A0A6M3Q7S1A0A6M3Q7S1_DROMESarm1178
M9PHR5M9PHR5_DROMESarm1704
M9NE45M9NE45_DROMESarm1730
M9NFP2M9NFP2_DROMESarm1059

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias25-39Basic and acidic residues
Compositional bias182-222Polar residues
Compositional bias232-251Polar residues
Compositional bias282-308Polar residues
Compositional bias1248-1263Polar residues
Compositional bias1500-1518Polar residues
Compositional bias1526-1556Basic and acidic residues
Compositional bias1557-1591Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014296
EMBL· GenBank· DDBJ
ABW08490.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp