A8IQE0 · CCD39_CHLRE
- ProteinCoiled-coil domain-containing protein 39
- GeneCCDC39
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids894 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, by acting as a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (PubMed:25395538).
Together with CCDC40/FAP172 forms a 96-nm-long complex in flagella. This complex does not act as a physical ruler, but rather act as a negative regulator for radial spokes: the complex lays along specific protofilaments, masking radial spoke binding sites and allowing recruitment of inner dynein arm (IDA) and nexin-dynein regulatory complexes (N-DRC) (PubMed:25395538).
Together with CCDC40/FAP172 forms a 96-nm-long complex in flagella. This complex does not act as a physical ruler, but rather act as a negative regulator for radial spokes: the complex lays along specific protofilaments, masking radial spoke binding sites and allowing recruitment of inner dynein arm (IDA) and nexin-dynein regulatory complexes (N-DRC) (PubMed:25395538).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axoneme | |
Cellular Component | motile cilium | |
Biological Process | cilium movement | |
Biological Process | inner dynein arm assembly |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCoiled-coil domain-containing protein 39
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Chlorophyta > core chlorophytes > Chlorophyceae > CS clade > Chlamydomonadales > Chlamydomonadaceae > Chlamydomonas
Accessions
- Primary accessionA8IQE0
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Short and immotile flagella. Inner dynein arm (IDA) and nexin-dynein regulatory complex (N-DRC) components are absent or severely reduced. Radial spokes are attached to doublet microtubules with an irregular periodicity of 32 nm instead of 96 nm.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000405820 | 1-894 | Coiled-coil domain-containing protein 39 | |||
Sequence: MANIDPYRTEEELVEDDEEVDMSFLPPFAKGTENEVLYVENARMERRLERTERALETNMDRLHIMDEHLKNVQQELKYTQTRVEAKNKEIESEKHLNAMAEREMGRLKKDIGKMEAERQELADKINGLQNQIYKNNEKLDQFKMLMNWNQEELEQWALAERQKAEDNAALEKYRHADDGKVKELTLALERVSKQVVGRKEELEAEVVETQAAQIQLDKAAEDFRKLHVERQDLIRQWEEAVEAMRHRDAAIAAASEQFAMQKDVLRERKRELDAQARFLENETLNTKEADARVAYYEREVGKQRDVLAREQARTEELNNQVELVKATLSKAATELAQRTVENKQAREDLDAKRQKLDAARKRFVVLKRKLENEFGNLDSMEAKASELEAMRRGEEARLKAILKEHELLKKEQYKRSQVLFDLRQKERELISEISGGQGQNKNLAARIHALDEQVVARAGGVRSEEETRALNARIEKLTAILEGVKRAEDDLLAARRANTSLRADRAKLDETISTLKLENDMVSRQVKGSVEAREKALVDHDVLALEVKRLRDILAAHADEVFSLENRKQQLALSMEERKQEVEVHRDGLRAELRLLREDVHRITLELKERLLRCEKLQAKFEIISAKHRGSGEDDGEERTQAYYVIKAAQEREALQREGDDLDGRIRVAEKEVAALEATLAQLMAVNTNFAASYKKVGSKEAFEERAALRDKLDKAYDKLKARRADEAAIAGDIQVSEARLSNLGQEQRSLQALVDDMTRRKAEAQRQLDEQREKLGRALGRTDKLRQKLGLANSPQGADVELAEVRDVTRAMLLELKALALANPGAMIAEACEAAGIRLPSGGSNPPSLGGSRPGSARSQTSLGSVRSARSVASQQRGGMGGSPAVRTIQLGA |
Post-translational modification
Phosphorylated in flagella.
Keywords
- PTM
Proteomic databases
Interaction
Subunit
Interacts with CCDC40/FAP172.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | A8IQE0 | CCDC40 A8IQT2 | 2 | EBI-16127597, EBI-16127612 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 32-143 | |||||
Sequence: TENEVLYVENARMERRLERTERALETNMDRLHIMDEHLKNVQQELKYTQTRVEAKNKEIESEKHLNAMAEREMGRLKKDIGKMEAERQELADKINGLQNQIYKNNEKLDQFK | ||||||
Coiled coil | 187-411 | |||||
Sequence: ALERVSKQVVGRKEELEAEVVETQAAQIQLDKAAEDFRKLHVERQDLIRQWEEAVEAMRHRDAAIAAASEQFAMQKDVLRERKRELDAQARFLENETLNTKEADARVAYYEREVGKQRDVLAREQARTEELNNQVELVKATLSKAATELAQRTVENKQAREDLDAKRQKLDAARKRFVVLKRKLENEFGNLDSMEAKASELEAMRRGEEARLKAILKEHELLKKE | ||||||
Coiled coil | 461-609 | |||||
Sequence: VRSEEETRALNARIEKLTAILEGVKRAEDDLLAARRANTSLRADRAKLDETISTLKLENDMVSRQVKGSVEAREKALVDHDVLALEVKRLRDILAAHADEVFSLENRKQQLALSMEERKQEVEVHRDGLRAELRLLREDVHRITLELKE | ||||||
Coiled coil | 647-788 | |||||
Sequence: KAAQEREALQREGDDLDGRIRVAEKEVAALEATLAQLMAVNTNFAASYKKVGSKEAFEERAALRDKLDKAYDKLKARRADEAAIAGDIQVSEARLSNLGQEQRSLQALVDDMTRRKAEAQRQLDEQREKLGRALGRTDKLRQ | ||||||
Region | 844-894 | Disordered | ||||
Sequence: GSNPPSLGGSRPGSARSQTSLGSVRSARSVASQQRGGMGGSPAVRTIQLGA | ||||||
Compositional bias | 846-879 | Polar residues | ||||
Sequence: NPPSLGGSRPGSARSQTSLGSVRSARSVASQQRG |
Sequence similarities
Belongs to the CCDC39 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length894
- Mass (Da)101,488
- Last updated2007-12-04 v1
- Checksum2E0A53532FA9E717
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 846-879 | Polar residues | ||||
Sequence: NPPSLGGSRPGSARSQTSLGSVRSARSVASQQRG |