A8IQE0 · CCD39_CHLRE

Function

function

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, by acting as a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (PubMed:25395538).
Together with CCDC40/FAP172 forms a 96-nm-long complex in flagella. This complex does not act as a physical ruler, but rather act as a negative regulator for radial spokes: the complex lays along specific protofilaments, masking radial spoke binding sites and allowing recruitment of inner dynein arm (IDA) and nexin-dynein regulatory complexes (N-DRC) (PubMed:25395538).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxoneme
Cellular Componentmotile cilium
Biological Processcilium movement
Biological Processinner dynein arm assembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Coiled-coil domain-containing protein 39
  • Alternative names
    • Flagellar-associated protein 59

Gene names

    • Name
      CCDC39
    • Synonyms
      FAP59
    • ORF names
      CHLREDRAFT_189109

Organism names

Accessions

  • Primary accession
    A8IQE0

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Short and immotile flagella. Inner dynein arm (IDA) and nexin-dynein regulatory complex (N-DRC) components are absent or severely reduced. Radial spokes are attached to doublet microtubules with an irregular periodicity of 32 nm instead of 96 nm.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004058201-894Coiled-coil domain-containing protein 39

Post-translational modification

Phosphorylated in flagella.

Keywords

Proteomic databases

Interaction

Subunit

Interacts with CCDC40/FAP172.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY A8IQE0CCDC40 A8IQT22EBI-16127597, EBI-16127612

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for coiled coil, region, compositional bias.

TypeIDPosition(s)Description
Coiled coil32-143
Coiled coil187-411
Coiled coil461-609
Coiled coil647-788
Region844-894Disordered
Compositional bias846-879Polar residues

Sequence similarities

Belongs to the CCDC39 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    894
  • Mass (Da)
    101,488
  • Last updated
    2007-12-04 v1
  • Checksum
    2E0A53532FA9E717
MANIDPYRTEEELVEDDEEVDMSFLPPFAKGTENEVLYVENARMERRLERTERALETNMDRLHIMDEHLKNVQQELKYTQTRVEAKNKEIESEKHLNAMAEREMGRLKKDIGKMEAERQELADKINGLQNQIYKNNEKLDQFKMLMNWNQEELEQWALAERQKAEDNAALEKYRHADDGKVKELTLALERVSKQVVGRKEELEAEVVETQAAQIQLDKAAEDFRKLHVERQDLIRQWEEAVEAMRHRDAAIAAASEQFAMQKDVLRERKRELDAQARFLENETLNTKEADARVAYYEREVGKQRDVLAREQARTEELNNQVELVKATLSKAATELAQRTVENKQAREDLDAKRQKLDAARKRFVVLKRKLENEFGNLDSMEAKASELEAMRRGEEARLKAILKEHELLKKEQYKRSQVLFDLRQKERELISEISGGQGQNKNLAARIHALDEQVVARAGGVRSEEETRALNARIEKLTAILEGVKRAEDDLLAARRANTSLRADRAKLDETISTLKLENDMVSRQVKGSVEAREKALVDHDVLALEVKRLRDILAAHADEVFSLENRKQQLALSMEERKQEVEVHRDGLRAELRLLREDVHRITLELKERLLRCEKLQAKFEIISAKHRGSGEDDGEERTQAYYVIKAAQEREALQREGDDLDGRIRVAEKEVAALEATLAQLMAVNTNFAASYKKVGSKEAFEERAALRDKLDKAYDKLKARRADEAAIAGDIQVSEARLSNLGQEQRSLQALVDDMTRRKAEAQRQLDEQREKLGRALGRTDKLRQKLGLANSPQGADVELAEVRDVTRAMLLELKALALANPGAMIAEACEAAGIRLPSGGSNPPSLGGSRPGSARSQTSLGSVRSARSVASQQRGGMGGSPAVRTIQLGA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias846-879Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS496120
EMBL· GenBank· DDBJ
EDP04876.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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