A8FFU1 · NTPPA_BACP2
- ProteindTTP/UTP pyrophosphatase
- Genemaf
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids189 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Catalytic activity
- dTTP + H2O = diphosphate + dTMP + H+
Cofactor
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 12 | Important for substrate specificity | ||||
Sequence: R | ||||||
Active site | 69 | Proton acceptor | ||||
Sequence: D | ||||||
Site | 70 | Important for substrate specificity | ||||
Sequence: T | ||||||
Site | 152 | Important for substrate specificity | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | dTTP diphosphatase activity | |
Molecular Function | UTP diphosphatase activity | |
Biological Process | nucleotide metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namedTTP/UTP pyrophosphatase
- EC number
- Short namesdTTPase/UTPase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus
Accessions
- Primary accessionA8FFU1
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000146283 | 1-189 | dTTP/UTP pyrophosphatase | |||
Sequence: MNQLILASQSPRRKELLDLAGFSYDIQASHLKEEINRNLSPAENVQWLAEQKANDIQRLNPKAVVIGADTIVAIDGKCLGKPKDKKEAAFMLQLLSGKTHQVLTGVTVQSENRKETFYEQTEVTFWTLTQNEIDRYIETGEPLDKAGSYGIQGKGALFVQKIDGDYFSVVGLPIAKTVRVLETFGITPF |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length189
- Mass (Da)21,058
- Last updated2007-11-13 v1
- Checksum924971618002C1B7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000813 EMBL· GenBank· DDBJ | ABV63108.1 EMBL· GenBank· DDBJ | Genomic DNA |