A8FFU1 · NTPPA_BACP2

Function

function

Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for site, active site.

TypeIDPosition(s)Description
Site12Important for substrate specificity
Active site69Proton acceptor
Site70Important for substrate specificity
Site152Important for substrate specificity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctiondTTP diphosphatase activity
Molecular FunctionUTP diphosphatase activity
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dTTP/UTP pyrophosphatase
  • EC number
  • Short names
    dTTPase/UTPase
  • Alternative names
    • Nucleoside triphosphate pyrophosphatase
    • Nucleotide pyrophosphatase
      (Nucleotide PPase
      )

Gene names

    • Name
      maf
    • Ordered locus names
      BPUM_2445

Organism names

Accessions

  • Primary accession
    A8FFU1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001462831-189dTTP/UTP pyrophosphatase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the Maf family. YhdE subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    189
  • Mass (Da)
    21,058
  • Last updated
    2007-11-13 v1
  • Checksum
    924971618002C1B7
MNQLILASQSPRRKELLDLAGFSYDIQASHLKEEINRNLSPAENVQWLAEQKANDIQRLNPKAVVIGADTIVAIDGKCLGKPKDKKEAAFMLQLLSGKTHQVLTGVTVQSENRKETFYEQTEVTFWTLTQNEIDRYIETGEPLDKAGSYGIQGKGALFVQKIDGDYFSVVGLPIAKTVRVLETFGITPF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000813
EMBL· GenBank· DDBJ
ABV63108.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp