A8DZ02 · A8DZ02_DROME
- ProteinADAM10 endopeptidase
- Genekuz
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1219 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Cofactor
Features
Showing features for binding site, active site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | perivitelline space | |
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | axon guidance | |
Biological Process | border follicle cell migration | |
Biological Process | cardiocyte differentiation | |
Biological Process | central nervous system development | |
Biological Process | glial cell migration | |
Biological Process | heart morphogenesis | |
Biological Process | lymph gland development | |
Biological Process | membrane protein ectodomain proteolysis | |
Biological Process | muscle tissue development | |
Biological Process | neuroblast fate determination | |
Biological Process | Notch signaling pathway | |
Biological Process | oogenesis | |
Biological Process | pericardial nephrocyte differentiation | |
Biological Process | positive regulation of border follicle cell migration | |
Biological Process | regulation of axon extension | |
Biological Process | regulation of Roundabout signaling pathway | |
Biological Process | ventral cord development |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameADAM10 endopeptidase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionA8DZ02
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-24 | Helical | ||||
Sequence: AFNIVFVSIIFIIIVNGYA |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 157-196 | Disordered | ||||
Sequence: TNRTATTTPPSTSTTSSATTATKSTQPTRPLAKSNTSTTA | ||||||
Compositional bias | 210-236 | Polar residues | ||||
Sequence: ESTTTSQQLPEYTESSSSSTTTFPPTT | ||||||
Region | 210-245 | Disordered | ||||
Sequence: ESTTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKER | ||||||
Region | 307-337 | Disordered | ||||
Sequence: YQKLHRKQLHKKSAPQQQQQPHPPKKYISGD | ||||||
Region | 384-410 | Disordered | ||||
Sequence: VRRATDNGAGDRGSSGGSGRGREDNKN | ||||||
Domain | 430-658 | Peptidase M12B | ||||
Sequence: IADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVL | ||||||
Domain | 675-781 | Disintegrin | ||||
Sequence: GAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETECSWSSTCNGTTAECPEPRHRDD | ||||||
Region | 935-1080 | Disordered | ||||
Sequence: TPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRGGGGGGGGRHGGSRSHHQQHPHDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRSDGRGPRSTSSGRPQAIASGSGAASGAARSHGG | ||||||
Compositional bias | 1030-1065 | Polar residues | ||||
Sequence: PTGGSHSSRNSAANQARRSDGRGPRSTSSGRPQAIA | ||||||
Region | 1109-1219 | Disordered | ||||
Sequence: QLPLPLPPPNGQQQMQQQQQLQLQQPAISPQQQPQQAFYTPKGVAPPPLQVSFSRPTSLHEQQQQQHHLQQQQQHQQQLEPQQQHAYADAYAALGRGQYESTTRAPNNSKV | ||||||
Compositional bias | 1119-1147 | Polar residues | ||||
Sequence: GQQQMQQQQQLQLQQPAISPQQQPQQAFY | ||||||
Compositional bias | 1159-1192 | Polar residues | ||||
Sequence: VSFSRPTSLHEQQQQQHHLQQQQQHQQQLEPQQQ |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,219
- Mass (Da)135,260
- Last updated2010-11-30 v2
- Checksum69DCE5F48B592EB7
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 210-236 | Polar residues | ||||
Sequence: ESTTTSQQLPEYTESSSSSTTTFPPTT | ||||||
Compositional bias | 1030-1065 | Polar residues | ||||
Sequence: PTGGSHSSRNSAANQARRSDGRGPRSTSSGRPQAIA | ||||||
Compositional bias | 1119-1147 | Polar residues | ||||
Sequence: GQQQMQQQQQLQLQQPAISPQQQPQQAFY | ||||||
Compositional bias | 1159-1192 | Polar residues | ||||
Sequence: VSFSRPTSLHEQQQQQHHLQQQQQHQQQLEPQQQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014134 EMBL· GenBank· DDBJ | ABV53680.2 EMBL· GenBank· DDBJ | Genomic DNA |