A8DU40 · A8DU40_SAISC

Function

function

Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Molecular FunctionC-C chemokine receptor activity
Molecular Functionchemokine (C-C motif) ligand 5 binding
Biological Processcalcium-mediated signaling
Biological Processcell chemotaxis
Biological Processimmune response
Biological Processinflammatory response
Biological Processpositive regulation of cytosolic calcium ion concentration

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    C-C chemokine receptor type 5

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Saimiriinae > Saimiri

Accessions

  • Primary accession
    A8DU40

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane9-28Helical
Transmembrane48-71Helical
Transmembrane83-107Helical
Transmembrane139-162Helical
Transmembrane174-194Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-197G-protein coupled receptors family 1 profile

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    197
  • Mass (Da)
    22,866
  • Last updated
    2007-11-13 v1
  • Checksum
    56A561D8ADA369B6
RLKNMTDIYLLNLAISDLLFLFTVPFWAHYAAGQWDFGNTMCQFLTALYFIGFFSGIFFIILLTIVFYLAIVHAVFALKARTVTFGLLTSVITWVVAVFASLPGIIFTRSQKEGYHYSCSPHFPSSQYRFWKNFETLKMVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIAYFLFWAPYXIVLL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue197

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ993155
EMBL· GenBank· DDBJ
ABJ99488.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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