A8CZZ8 · SP153_IXORI

Function

function

Salivary tick protein that downregulates host immune system by binding to both dendritic cells, and CD4+ T cells. Specifically binds to the CD4 coreceptor on T cells. This interaction prevents the activation of the Src kinase, Lck, and its downstream substrate Zap-70, and results in deficient activation of PLCgamma1, the repression of calcium fluxes triggered by T-cell antigen receptor (TCR) ligation, and a subsequent reduction in interleukin-2 production. This salivary protein also binds to DC-SIGN (CD209) on dendritic cells (DC) and activates the Raf-1 kinase/MEK signaling pathway that results in down-regulating expression of pro-inflammatory cytokines. Furthermore, it inhibits T cell proliferation induced by DCs (By similarity).
In addition, it inhibits in vitro keratinocyte inflammation induced by Borrelia burgdorferi or by the major outer surface protein (OspC) of Borrelia (By similarity).
In addition, it downregulates chemokines and monocyte chemoattractant protein 1, as well as several antimicrobial peptides such as defensins, cathelicidin, psoriasin, and RNase 7 (By similarity).
Apart from its immunomodulatory activities, it is also associated with protection of Borrelia spirochetes from antibody-mediated killing through its binding to OspC (By similarity) (PubMed:33401196).
In vivo, tests on different immune disease animal models show promising therapeutic results, e.g., in inhibiting HIV infection, experimental autoimmune encephalomyelitis, transplantation rejection, and asthma (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region

Names & Taxonomy

Protein names

  • Recommended name
    Salivary protein 15 Iric-3
  • Short names
    Salp15 Iric-3
  • Alternative names
    • Salp15-like

Organism names

Accessions

  • Primary accession
    A8CZZ8

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

Type
IDPosition(s)Description
Signal1-22
ChainPRO_500271853123-124Salivary protein 15 Iric-3
Glycosylation82N-linked (GlcNAc...) asparagine
Glycosylation93N-linked (GlcNAc...) asparagine

Keywords

Expression

Tissue specificity

Expressed in salivary glands (PubMed:17896872).
Detected in fed adult female (PubMed:17896872).

Induction

By feeding (Probable). By the presence of Borrelia burgdorferi (By similarity).

Interaction

Subunit

Interacts with host CD4 (By similarity).
Interacts with host DC-SIGN (CD209) (By similarity).
Interacts with Borrelia outer surface protein C (OspC) (PubMed:33401196).

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region105-124CD4-binding

Sequence similarities

Belongs to the salp15 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    124
  • Mass (Da)
    13,846
  • Last updated
    2007-11-13 v1
  • Checksum
    F127F263420FD369
MESFVAMKVVCIILLFVIAAEAESINEKSDVEPSKGKNNSGLQFKFPPYVPNHKAFALRLLSLCEQGIYGTKINDLKVDFKNCTFLCIRKYENLTLPLPEDTPCGPNNQTCHKKDECVGYIPGC

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU128528
EMBL· GenBank· DDBJ
ABU93615.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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