A8BM50 · ATAT_GIAIC
- ProteinAlpha-tubulin N-acetyltransferase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids362 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Catalytic activity
- L-lysyl-[alpha-tubulin] + acetyl-CoA = N6-acetyl-L-lysyl-[alpha-tubulin] + CoA + H+
Features
Showing features for site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 52 | Crucial for catalytic activity | |||
Binding site | 111-124 | acetyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 147-156 | acetyl-CoA (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | microtubule | |
Molecular Function | tubulin N-acetyltransferase activity | |
Biological Process | alpha-tubulin acetylation | |
Biological Process | regulation of microtubule cytoskeleton organization |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-tubulin N-acetyltransferase
- EC number
- Short namesAlpha-TAT ; TAT
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metamonada > Diplomonadida > Hexamitidae > Giardiinae > Giardia
Accessions
- Primary accessionA8BM50
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000402089 | 1-362 | Alpha-tubulin N-acetyltransferase | ||
Structure
Sequence
- Sequence statusComplete
- Length362
- Mass (Da)40,672
- Last updated2007-11-13 v1
- ChecksumE5A6E3F6752E3D97
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AACB02000025 EMBL· GenBank· DDBJ | EDO78575.1 EMBL· GenBank· DDBJ | Genomic DNA |