A8B4Q0 · TRM5_GIAIC

Function

function

Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

Catalytic activity

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site241S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site285-286S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site313-314S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Cellular Componentnucleus
Molecular FunctiontRNA (guanine(37)-N1)-methyltransferase activity
Biological ProcesstRNA methylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA (guanine(37)-N(1))-methyltransferase
  • EC number
  • Alternative names
    • M1G-methyltransferase
    • tRNA [GM37] methyltransferase
    • tRNA methyltransferase 5 homolog

Gene names

    • ORF names
      GL50803_4164

Organism names

Accessions

  • Primary accession
    A8B4Q0

Organism-specific databases

Subcellular Location

Mitochondrion matrix
Nucleus
Cytoplasm
Note: Predominantly in the mitochondria and in the nucleus.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004141571-447tRNA (guanine37-N1)-methyltransferase

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    447
  • Mass (Da)
    50,511
  • Last updated
    2007-11-13 v1
  • Checksum
    A88DBE14CEC869FB
MSHQRPEIFDNFAGAQVMTVDGEPQRDLNQARRIVLEMKEPLCRIPEDLRSLLSVTISVYCIETPSALVSTIIKNMPPEASIALVTGCRFLAVRDGPRGKTVTVLSTAFLSGLDESVTQQLFIHADTLLLTPEARSRISLLQDIIEDPPTSFETVGHIAHYNLREAHLPYRYFIGAVTCEKEPAITTVITKIDTVQSQYRTYNFELIGGVPRYDVKLVQDGITYSFNYTKVYWNSRLSHEHLSLAQHINQTICPNDLVLDGTCGIGPHALLLAKRFNFTNLICNDLNPDAYKSLKMNVRINKAENAITCFNEDVSSLLRRLLPETNLKAVIFSLPELSINLLQAMKGVPDIYCFLECFTRAPPHLAYYDLLLRCSESLLDTKVCTGIQQALSDIEKVAENKELIDLLIACYETFEVKEIRTVSTNKFMYRVTLKINEQKETVKVLKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AACB02000002
EMBL· GenBank· DDBJ
EDO81986.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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