A8AXZ6 · AROD_STRGC

Function

function

Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site63-dehydroquinate (UniProtKB | ChEBI)
Binding site30-323-dehydroquinate (UniProtKB | ChEBI)
Binding site623-dehydroquinate (UniProtKB | ChEBI)
Active site118Proton donor/acceptor
Active site143Schiff-base intermediate with substrate
Binding site1863-dehydroquinate (UniProtKB | ChEBI)
Binding site2053-dehydroquinate (UniProtKB | ChEBI)
Binding site2093-dehydroquinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3-dehydroquinate dehydratase activity
Biological Process3,4-dihydroxybenzoate biosynthetic process
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-dehydroquinate dehydratase
  • EC number
  • Short names
    3-dehydroquinase
  • Alternative names
    • Type I DHQase
    • Type I dehydroquinase
      (DHQ1
      )

Gene names

    • Name
      aroD
    • Ordered locus names
      SGO_1375

Organism names

Accessions

  • Primary accession
    A8AXZ6

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000780511-2253-dehydroquinate dehydratase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the type-I 3-dehydroquinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    225
  • Mass (Da)
    25,730
  • Last updated
    2007-10-23 v1
  • Checksum
    4370521B912359A8
MKLVVSVTPRNLEEAQQIDAQRFVDADLIEWRADFLEKEEILKVAPAIFEKFAGRELIFTLRTKDEGGHIQLSDDEYVEMIKKVAQLYQPDYVDFEYFSHKDKIDEMLEFPNLVLSYHNFEETPENMMEILSELTSLTPKAVKVSVMANSGQDVLDLMNYTRGFKTLNPEQEYVTISMGRVGRISRIASDLTGSSWSFASLDEATAPGQISLSSMKKIRDILNEN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000725
EMBL· GenBank· DDBJ
ABV10967.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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