A8ADR3 · ACCD_CITK8

Function

function

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site27Zn2+ (UniProtKB | ChEBI)
Binding site30Zn2+ (UniProtKB | ChEBI)
Binding site46Zn2+ (UniProtKB | ChEBI)
Binding site49Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentacetyl-CoA carboxylase complex
Molecular Functionacetyl-CoA carboxylase activity
Molecular FunctionATP binding
Molecular Functioncarboxyl- or carbamoyltransferase activity
Molecular Functionzinc ion binding
Biological Processfatty acid biosynthetic process
Biological Processmalonyl-CoA biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
  • EC number
  • Short names
    ACCase subunit beta
    ; Acetyl-CoA carboxylase carboxyltransferase subunit beta

Gene names

    • Name
      accD
    • Ordered locus names
      CKO_00470

Organism names

Accessions

  • Primary accession
    A8ADR3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003589641-304Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Interaction

Subunit

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, zinc finger, region.

TypeIDPosition(s)Description
Domain23-292CoA carboxyltransferase N-terminal
Zinc finger27-49C4-type
Region281-304Disordered

Sequence similarities

Belongs to the AccD/PCCB family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    304
  • Mass (Da)
    33,372
  • Last updated
    2007-10-23 v1
  • Checksum
    8EFFCFEBB497D551
MSWIERIKSNITPTRKASIPEGVWTKCDSCGQVLYRAELERNLEVCPKCDHHMRMSARNRLHSLLDEGSLVELGSELEPKDVLKFRDSKKYKDRLASAQKETGEKDALVVMKGTLHDMPIVAAAFEFSFMGGSMGSVVGARFVRAVEQALEDNCPLICFSASGGARMQEALMSLMQMAKTSAALAKMQERGLPYISVLTDPTMGGVSASFAMLGDLNIAEPKALIGFAGPRVIEQTVREKLPPGFQRSEFLIEKGAIDMIVRRPEMRLKLASVLAKLMNLPAPNPDAPREGEVVPPVPDQEPEA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000822
EMBL· GenBank· DDBJ
ABV11626.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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